Applying therapeutic peptide design principles to agricultural peptides - Nature

Peptides offer a biodegradable, specific alternative to conventional pesticides, with the potential to address resistance and reduce harm to beneficial species. Here we argue that adopting the design playbook of peptide therapeutics, from library screening to de novo design strategies, could accelerate the development of precise, field-ready agricultural peptide products.

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Acknowledgements

J.H.C. is supported from an Australian Research Council (ARC) Discovery Project (DP230100590). D.J.C. was supported by a National Health and Medical Research Council (Australia) Leadership Fellowship (2009564) and the ARC (CE200100012). C.K.W. is an ARC Future Fellow (FT220100583).

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Cobon, J.H., Craik, D.J. & Wang, C.K. Applying therapeutic peptide design principles to agricultural peptides. Nat Rev Bioeng (2026). https://doi.org/10.1038/s44222-026-00461-3

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- DOI: https://doi.org/10.1038/s44222-026-00461-3