{"id":34939,"topic":"peptides","source":"Nature","title":"Applying therapeutic peptide design principles to agricultural peptides - Nature","url":"https://www.nature.com/articles/s44222-026-00461-3","url_hash":"0f4ac71918a2391531ebebe9a266c6bd5f9977a1","author":"","summary":"<a href=\"https://news.google.com/rss/articles/CBMiX0FVX3lxTE1YMlhUYVhPdTdpNEh6bzMxSHVKUzJaWHJEbjJNZjlHc1ZGRlFTYmhGdE10LVRXV0l4TUxBYS1CUWF5SThoanE4SU84eGRTNGJxU1JnY3RkVmhHQ2dwNkpF?oc=5\" target=\"_blank\">Applying therapeutic peptide design principles to agricultural peptides</a>&nbsp;&nbsp;<font color=\"#6f6f6f\">Nature</font>","content":"Peptides offer a biodegradable, specific alternative to conventional pesticides, with the potential to address resistance and reduce harm to beneficial species. Here we argue that adopting the design playbook of peptide therapeutics, from library screening to de novo design strategies, could accelerate the development of precise, field-ready agricultural peptide products.\nAccess options\nSubscribe to this journal\nReceive 12 digital issues and online access to articles\n118,99 € per year\nonly 9,92 € per issue\nBuy this article\n39,95 €\nPrices may be subject to local taxes which are calculated during checkout\nReferences\n- Muttenthaler, M. et al. Trends in peptide drug discovery. Nat. Rev. Drug Discov. 20, 309–325 (2021). \n- Davis, B. R. et al. Proteolytic stabilization of a spider venom peptide results in an orally active bioinsecticide. Pest Manage. Sci. 81, 6404–6415 (2025). \n- Food and Agriculture Organisation of the United Nations.2024.Pesticides use and trade, 1990–2022. https://doi.org/10.4060/cd1486en. \n- Nicholson, C. C. et al. Pesticide use negatively affects bumble bees across European landscapes. Nature 628, 355–358 (2024). \n- Kergaravat, B. et al. Enzymes, proteins, and peptides as promising biosolutions for crop production. J. Agric. Food Chem. 73, 11546–11555 (2025). \n- Poth, A. G. et al. Discovery of cyclotides in the fabaceae plant family provides new insights into the cyclization, evolution, and distribution of circular proteins. ACS Chem. Biol. 6, 345–355 (2011). \n- Fox, D. R. et al. Code to complex: AI-driven de novo binder design. Structure 33, 1631–1642 (2025). \n- Hong, L. et al. AI-designed peptides as tools for biochemistry. Biochem. 65, 1071–1083 (2026). \n- Sukiran, N. A. et al. Enhancing the oral and topical insecticidal efficacy of a commercialized spider venom peptide biopesticide via fusion to the carrier snowdrop lectin (Galanthus nivalis agglutinin). Pest Manage. Sci. 79, 284–294 (2023). \n- Jumper, J. et al. Highly accurate protein structure prediction with AlphaFold. Nature 596, 583–589 (2021). \nAcknowledgements\nJ.H.C. is supported from an Australian Research Council (ARC) Discovery Project (DP230100590). D.J.C. was supported by a National Health and Medical Research Council (Australia) Leadership Fellowship (2009564) and the ARC (CE200100012). C.K.W. is an ARC Future Fellow (FT220100583).\nAuthor information\nAuthors and Affiliations\nCorresponding author\nAbout this article\nCite this article\nCobon, J.H., Craik, D.J. & Wang, C.K. Applying therapeutic peptide design principles to agricultural peptides. Nat Rev Bioeng (2026). https://doi.org/10.1038/s44222-026-00461-3\n- Published: \n- Version of record: \n- DOI: https://doi.org/10.1038/s44222-026-00461-3","image_url":"https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs44222-026-00461-3/MediaObjects/44222_2026_461_Fig1_HTML.png","lang":"en","published_at":"2026-05-29T07:00:00+00:00","fetched_at":"2026-07-13T01:15:08+00:00","status":"read","starred":0,"extract_state":"ok","summary_auto":"Peptides offer a biodegradable, specific alternative to conventional pesticides, with the potential to address resistance and reduce harm to beneficial species. 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Here we argue that adopting the design playbook of peptide therapeutics, from library screening to de novo design strategies, could accelerate the development of precise, field-ready agricultural peptide products.\nAccess options\nSubscribe to this journal\nReceive 12 digital issues and online access to articles\n118,99 € per year\nonly 9,92 € per issue\nBuy this article\n39,95 €\nPrices may be subject to local taxes which are calculated during checkout\nReferences\n- Muttenthaler, M. et al. Trends in peptide drug discovery. Nat. Rev. Drug Discov. 20, 309–325 (2021). \n- Davis, B. R. et al. Proteolytic stabilization of a spider venom peptide results in an orally active bioinsecticide. Pest Manage. Sci. 81, 6404–6415 (2025). \n- Food and Agriculture Organisation of the United Nations.2024.Pesticides use and trade, 1990–2022. https://doi.org/10.4060/cd1486en. \n- Nicholson, C. C. et al. Pesticide use negatively affects bumble bees across European landscapes. 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Nature 596, 583–589 (2021). \nAcknowledgements\nJ.H.C. is supported from an Australian Research Council (ARC) Discovery Project (DP230100590). D.J.C. was supported by a National Health and Medical Research Council (Australia) Leadership Fellowship (2009564) and the ARC (CE200100012). C.K.W. is an ARC Future Fellow (FT220100583).\nAuthor information\nAuthors and Affiliations\nCorresponding author\nAbout this article\nCite this article\nCobon, J.H., Craik, D.J. & Wang, C.K. Applying therapeutic peptide design principles to agricultural peptides. Nat Rev Bioeng (2026). https://doi.org/10.1038/s44222-026-00461-3\n- Published: \n- Version of record: \n- DOI: https://doi.org/10.1038/s44222-026-00461-3","excerpt":"Peptides offer a biodegradable, specific alternative to conventional pesticides, with the potential to address resistance and reduce harm to beneficial species. 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