{"id":93196,"topic":"peptides","source":"Yale School of Medicine","title":"View of Alzheimer’s Disease Peptide Could Inform New Drugs - Yale School of Medicine","url":"https://medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","url_hash":"912db3caeedcdf3508a791a2a2b22567348bab42","author":"","summary":"<a href=\"https://news.google.com/rss/articles/CBMiiwFBVV95cUxQZmRCU2Flb0RSUlVzQU1jTXNZem1sbjlVc2xMSGJydGp5SmtBRDFmZmJOcmVWM2ZpbTY0clFGSUlkWktUOTZXWjdJWVZVLVFHMlVFTk5ta0ZNVnhDOVc3T2RPZ0h4Y2FIWWpneXh3ZDhJZzRZM0dMMjF5MUlJaXBua0NHYXA3MndqSk04?oc=5\" target=\"_blank\">View of Alzheimer’s Disease Peptide Could Inform New Drugs</a>&nbsp;&nbsp;<font color=\"#6f6f6f\">Yale School of Medicine</font>","content":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when it’s damaging to the brain.\nAmyloid beta is a naturally occurring peptide that exists in healthy brains. But in Alzheimer’s disease, these peptides clump together abnormally and form large plaques. Scientists have known about the association between these plaques and Alzheimer’s disease for over a century, but whether this buildup is actually damaging the brain or simply a byproduct of the disease has been hotly debated.\nThere is also an intermediate state of amyloid beta that exists between the healthy peptides and the large plaques. Emerging evidence suggests that it is these intermediates—so called “oligomeric” amyloid beta—that are the drivers of damage to the brain, but their structure has remained unknown. Now, a team of researchers at Yale School of Medicine has characterized this intermediate form for the first time.","image_url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_jpg,h_630,q_auto,w_1200/v1/yms/prod/a6297b1c-7355-48f0-b394-ffb78bd1e040","lang":"en","published_at":"2026-07-29T07:00:00+00:00","fetched_at":"2026-09-30T01:15:08+00:00","status":"read","starred":0,"extract_state":"ok","summary_auto":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when it’s damaging to the brain.","cluster_id":null,"extract_retries":0,"extract_error":null,"contract_version":"news_item.v1","format_contract_version":"news_item_formats.v1","dedup_url":"https://medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 1056 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":1056,"summary_length":247,"usable_text_length":1056,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":1056,"summary_length":247}},"news_item":{"id":93196,"canonical_url":"https://medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","source_url":"https://medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","title":"View of Alzheimer’s Disease Peptide Could Inform New Drugs - Yale School of Medicine","source_name":"Yale School of Medicine","author":null,"published_at":"2026-07-29T07:00:00+00:00","locale":"en","topic":"peptides","tags":[],"rss_summary":"<a href=\"https://news.google.com/rss/articles/CBMiiwFBVV95cUxQZmRCU2Flb0RSUlVzQU1jTXNZem1sbjlVc2xMSGJydGp5SmtBRDFmZmJOcmVWM2ZpbTY0clFGSUlkWktUOTZXWjdJWVZVLVFHMlVFTk5ta0ZNVnhDOVc3T2RPZ0h4Y2FIWWpneXh3ZDhJZzRZM0dMMjF5MUlJaXBua0NHYXA3MndqSk04?oc=5\" target=\"_blank\">View of Alzheimer’s Disease Peptide Could Inform New Drugs</a>&nbsp;&nbsp;<font color=\"#6f6f6f\">Yale School of Medicine</font>","full_text":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when it’s damaging to the brain.\nAmyloid beta is a naturally occurring peptide that exists in healthy brains. But in Alzheimer’s disease, these peptides clump together abnormally and form large plaques. Scientists have known about the association between these plaques and Alzheimer’s disease for over a century, but whether this buildup is actually damaging the brain or simply a byproduct of the disease has been hotly debated.\nThere is also an intermediate state of amyloid beta that exists between the healthy peptides and the large plaques. Emerging evidence suggests that it is these intermediates—so called “oligomeric” amyloid beta—that are the drivers of damage to the brain, but their structure has remained unknown. Now, a team of researchers at Yale School of Medicine has characterized this intermediate form for the first time.","excerpt":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when it’s damaging to the brain.","extraction":{"state":"ok","confidence":0.9,"error":null,"explanation":"High confidence: full text extraction produced 1056 characters.","diagnostics_url":"/api/diagnose?url=https%3A//medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 1056 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":1056,"summary_length":247,"usable_text_length":1056,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":1056,"summary_length":247}}},"display_formats":["compact","card","full","digest_section","json"]},"daily_stack_record":{"title":"View of Alzheimer’s Disease Peptide Could Inform New Drugs - Yale School of Medicine","url":"https://medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","summary":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when it’s damaging to the brain.","source":"Yale School of Medicine","date":"2026-07-29T07:00:00+00:00","content":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when it’s damaging to the brain.\nAmyloid beta is a naturally occurring peptide that exists in healthy brains. But in Alzheimer’s disease, these peptides clump together abnormally and form large plaques. Scientists have known about the association between these plaques and Alzheimer’s disease for over a century, but whether this buildup is actually damaging the brain or simply a byproduct of the disease has been hotly debated.\nThere is also an intermediate state of amyloid beta that exists between the healthy peptides and the large plaques. Emerging evidence suggests that it is these intermediates—so called “oligomeric” amyloid beta—that are the drivers of damage to the brain, but their structure has remained unknown. Now, a team of researchers at Yale School of Medicine has characterized this intermediate form for the first time.","confidence":0.9,"diagnostics_url":"/api/diagnose?url=https%3A//medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","quality_bucket":"high","failure_kind":"none","retryable":false,"quality_reason":"High confidence: full text extraction produced 1056 characters.","quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 1056 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":1056,"summary_length":247,"usable_text_length":1056,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":1056,"summary_length":247}},"tags":[]},"fallback_formats":["markdown","json","html"],"actions":{"read":"/item/93196","export_markdown":"/api/items/93196/export?format=markdown","export_json":"/api/items/93196/export?format=json","diagnose":"/api/diagnose?url=https%3A//medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/"},"formats":{"full":{"id":93196,"title":"View of Alzheimer’s Disease Peptide Could Inform New Drugs - Yale School of Medicine","url":"https://medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","source":"Yale School of Medicine","author":null,"published_at":"2026-07-29T07:00:00+00:00","locale":"en","topic":"peptides","tags":[],"excerpt":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when it’s damaging to the brain.","full_text":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when it’s damaging to the brain.\nAmyloid beta is a naturally occurring peptide that exists in healthy brains. But in Alzheimer’s disease, these peptides clump together abnormally and form large plaques. Scientists have known about the association between these plaques and Alzheimer’s disease for over a century, but whether this buildup is actually damaging the brain or simply a byproduct of the disease has been hotly debated.\nThere is also an intermediate state of amyloid beta that exists between the healthy peptides and the large plaques. Emerging evidence suggests that it is these intermediates—so called “oligomeric” amyloid beta—that are the drivers of damage to the brain, but their structure has remained unknown. Now, a team of researchers at Yale School of Medicine has characterized this intermediate form for the first time.","reading_time_min":1,"extraction":{"state":"ok","confidence":0.9,"error":null,"explanation":"High confidence: full text extraction produced 1056 characters.","diagnostics_url":"/api/diagnose?url=https%3A//medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 1056 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":1056,"summary_length":247,"usable_text_length":1056,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":1056,"summary_length":247}}},"quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 1056 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":1056,"summary_length":247,"usable_text_length":1056,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":1056,"summary_length":247}},"actions":{"read":"/item/93196","export_markdown":"/api/items/93196/export?format=markdown","export_json":"/api/items/93196/export?format=json","diagnose":"/api/diagnose?url=https%3A//medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/"}},"digest":{"id":93196,"title":"View of Alzheimer’s Disease Peptide Could Inform New Drugs - Yale School of Medicine","url":"https://medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","source":"Yale School of Medicine","topic":"peptides","published_at":"2026-07-29T07:00:00+00:00","excerpt":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when it’s damaging to the brain.","quality_bucket":"high","quality_reason":"High confidence: full text extraction produced 1056 characters.","reading_time_min":1,"cluster_id":null},"card":{"display_title":"View of Alzheimer’s Disease Peptide Could Inform New Drugs - Yale School of Medicine","subtitle":"Yale School of Medicine · 2026-07-29","summary":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when…","badges":["quality:high"],"links":{"read":"/item/93196","original":"https://medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","diagnose":"/api/diagnose?url=https%3A//medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/"},"quality_warning":null},"export":{"title":"View of Alzheimer’s Disease Peptide Could Inform New Drugs - Yale School of Medicine","url":"https://medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","summary":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when it’s damaging to the brain.","source":"Yale School of Medicine","date":"2026-07-29T07:00:00+00:00","content":"One of the hallmarks of Alzheimer’s disease is the accumulation of a peptide in the brain known as amyloid beta. A new Nature Communications study published July 22 has uncovered the atomic structure of the peptide when it’s damaging to the brain.\nAmyloid beta is a naturally occurring peptide that exists in healthy brains. But in Alzheimer’s disease, these peptides clump together abnormally and form large plaques. Scientists have known about the association between these plaques and Alzheimer’s disease for over a century, but whether this buildup is actually damaging the brain or simply a byproduct of the disease has been hotly debated.\nThere is also an intermediate state of amyloid beta that exists between the healthy peptides and the large plaques. Emerging evidence suggests that it is these intermediates—so called “oligomeric” amyloid beta—that are the drivers of damage to the brain, but their structure has remained unknown. Now, a team of researchers at Yale School of Medicine has characterized this intermediate form for the first time.","confidence":0.9,"diagnostics_url":"/api/diagnose?url=https%3A//medicine.yale.edu/news-article/alzheimers-disease-peptide-inform-new-drugs/","quality_bucket":"high","failure_kind":"none","retryable":false,"quality_reason":"High confidence: full text extraction produced 1056 characters.","quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 1056 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":1056,"summary_length":247,"usable_text_length":1056,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":1056,"summary_length":247}},"tags":[],"format_contract_version":"news_item_formats.v1"}}}