{"id":91531,"topic":"peptides","source":"生物通","title":"儿童Alport综合征的无创诊断尿液肽组学标志物 - 生物通","url":"https://www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","url_hash":"b77f93253c0160eee587afea7976bcf6115b2096","author":"","summary":"<a href=\"https://news.google.com/rss/articles/CBMibEFVX3lxTE1BRjFZUE96T3FYU2xwc2FFOUVmMTRFZ2p1OUM0bndWRkFHTE9EU2NCeV8tRlE5cVdzXy02Mm5YU1o4cV9pc1JnamVTUnVEcUZXR3d5QXVTOUJMbndvN3IwMk1pYXNlQXUxN05PVQ?oc=5\" target=\"_blank\">儿童Alport综合征的无创诊断尿液肽组学标志物</a>&nbsp;&nbsp;<font color=\"#6f6f6f\">生物通</font>","content":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children\n        \n        \t\n            \t±à¼ÍÆ¼ö£º\n                \n                ¡¡¡¡ÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n                \n\t\t\t\t\n             \n            \n\t\t\t\n         \n        \n        ¡¡¡¡\nÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n·½·¨£º²ÉÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉµÄÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑéÖÐ57ÀýAS»¼¶ù£¨80.7%ÎªXÁ¬ËøÒÅ´«£¬Æ½¾ùÄêÁä10¡À4Ëê£¬Å®ÐÔÕ¼4%£¬Æ½¾ù¹ÀËãÉöÐ¡ÇòÂË¹ýÂÊ[eGFR]Îª128¡À31 mL/min/1.73 m2£©µÄ282·ÝÑù±¾£¬ÒÔ¼°À´×Ô¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxon¼ìÑé²¢¾Benjamini-HochbergÐ£Õý¼ø¶¨²îÒìëÄ£¬ÓÃÓÚ¹¹½¨Ö§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ºÍÔÚÑéÖ¤¶ÓÁÐÖÐµÄÓ¦ÓÃ½øÐÐÆÀ¹À¡£\n½á¹û£º¹²¼ø¶¨³ö151ÖÖ²îÒìëÄ¡£ÆäÖÐ87ÖÖëÄ¾ßÓÐÐòÁÐÐÅÏ¢²¢ÓÃÓÚ·ÖÀàÆ÷Éú³É£»60.9%Îª½ºÔµ°°×ÑÜÉúëÄ¡£ÔÚÑéÖ¤ÖÐ£¬¸Ã·ÖÀàÆ÷µÄÊÜÊÔÕß¹¤×÷ÌØÕ÷ÇúÏßÏÂÃæ»ý£¨AUC£©´ïµ½0.999£¨95%ÖÃÐÅÇø¼ä[CI] 0.997¨C1.000£©£¬ÁéÃô¶ÈÎª100%£¬ÌØÒì¶ÈÎª97.4%£¬×¼È·ÂÊÎª98.2%¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬ÆäÐÔÄÜÈÔÈ»½Ï¸ß£¨Ð£ÕýºóAUCÎª0.918£¬95% CI 0.884¨C0.951£©¡£×ÝÏò·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ³¤´ï3ÄêµÄËæ·ÃÆÚÄÚ±£³ÖÎÈ¶¨¡£\n½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖÓÃÓÚ¶ù¿ÆASÎÞ´´Õï¶ÏµÄ×¼È·ÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬²¢ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£\nÑÐ¾¿±³¾°ÓëÄ¿µÄ\nÒÅ´«ÐÔÉö²¡ÊÇ¶ùÍ¯ÖÕÄ©ÆÚÉö²¡µÄÖ÷ÒªÔÒòÖ®Ò»£¬ÆäÖÐAlport×ÛºÏÕ÷£¨AS£©ÊÇÓÉCOL4A3¡¢COL4A4»òCOL4A5»ùÒòÖÂ²¡ÐÔ±äÒìÒýÆðµÄÒÅ´«ÐÔÉöÔà¼²²¡£¬µ¼ÖÂIVÐÍ½ºÔ½á¹¹Òì³£ºÍ½øÐÐÐÔÉöÐ¡Çò»ùµ×Ä¤£¨GBM£©ËðÉË¡£ASÁÙ´²±íÏÖ¶àÑù£¬´Ó¹ÂÁ¢ÐÔÑªÄòµ½½øÐÐÐÔÂýÐÔÉöÔà²¡¡¢ÌýÁ¦É¥Ê§ºÍÑÛ²¿Òì³£²»µÈ¡£¶ùÍ¯ÆÚÔçÆÚÕï¶ÏÖÁ¹ØÖØÒª£¬ÒòÎªÊ¶±ðAS¿ÉÖ¸µ¼Ëæ·Ã²ßÂÔ¡¢¿ªÕ¹¼Ò×åÉ¸²é²¢¾¡ÔçÆô¶¯°üÀ¨ÉöËØ-Ñª¹Ü½ôÕÅËØÏµÍ³×è¶ÏÔÚÄÚµÄÉöÔà±£»¤ÖÎÁÆ£¬´Ó¶øÑÓ»º¼²²¡½øÕ¹¡£È»¶ø£¬¶ùÍ¯Õï¶ÏÃæÁÙÖî¶àÌôÕ½£ºÔçÆÚ±íÏÖÈç³ÖÐøÐÔ¾µÏÂÑªÄòÎª·ÇÌØÒìÐÔÖ¢×´£¬³£ÓëÆäËû¶ù¿ÆÉöÔà¼²²¡ÖØµþ£»¾¡¹Ü»ùÒò¼ì²âÒÑ³ÉÎªÕï¶ÏºËÐÄ£¬µ«ÏÖÓÐ²âÐò²ßÂÔÎÞ·¨¼ì³öËùÓÐÖÂ²¡±äÒì£¬Ô¼20%µÄÁÙ´²ÒÉËÆ»¼ÕßÎ´ÄÜÍ¨¹ý»ùÒò¼ì²âÈ·¶¨ÖÂ²¡±äÒì£¬ÔÒò°üÀ¨È«ÍâÏÔ×Ó×é²âÐòµÄ¼¼Êõ¾ÖÏÞ¡¢·Ç¾µä¼ô½Ó±äÒìµÄ¼ì²âÀ§ÄÑ¡¢Ç¶ºÏÌåÏÖÏóÒÔ¼°ÆäËûÉöÔà¼²²¡µ¼ÖÂµÄ±íÐÍÄ£ÄâµÈ¡£Éö»î¼ìËä¿ÉÌá¹©¶îÍâÕï¶ÏÐÅÏ¢£¬µ«ÆäÎªÇÖÈëÐÔ¼ì²é£¬ÇÒ¹â¾µÏÂ×éÖ¯Ñ§·¢ÏÖ¿ÉÄÜ·ÇÌØÒìÐÔ¡£ÕâÐ©¾ÖÏÞÐÔ´ÙÊ¹ÑÐ¾¿Õß¶Ô»ùÓÚÄòÒºµÄ·ÇÇÖÈëÐÔ·½·¨²úÉúÐËÈ¤£¬ÒÔÆÚÖ§³Ö¸üÔç¡¢¸ü±ã½ÝµÄAS¼ì²â¡£\nÑÐ¾¿·½·¨Óë½áÂÛ\nÑÐ¾¿ÈËÔ±ÀûÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑé£¨NCT01485978£©ÖÐ57ÀýAS»¼¶ùµÄ282·ÝÄòÒºÑù±¾£¬ÒÔ¼°À´×Ô¶à¸ö¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾×÷Îª±È½Ï¶ÓÁÐ£¬°üÀ¨ÏÈÌìÐÔÉöÔàºÍÄòÂ·»ûÐÎ£¨CAKUT£©¡¢¹£×èÐÔÄòÂ·²¡£¨OU£©¡¢³£È¾É«ÌåÒþÐÔÒÅ´«¶àÄÒÉö²¡£¨ARPKD£©¡¢ÉöÏûºÄÖ¢¡¢1ÐÍÌÇÄò²¡¡¢ÉöÄÒÖ×ºÍÌÇÄò²¡×ÛºÏÕ÷£¨RCAD£©»¼¶ù¼°½¡¿µ¶ùÍ¯¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxonÖÈºÍ¼ìÑé²¢¾Benjamini-Hochberg´íÎó·¢ÏÖÂÊ£¨FDR£©Ð£Õý½øÐÐÅä¶Ô±È½Ï£¬É¸Ñ¡³öÔÚËùÓÐ±È½ÏÖÐ·½ÏòÒ»ÖÂÇÒFDR<0.05µÄ²îÒìëÄ£¬×îÖÕÀûÓÃ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢µÄëÄ¶Î¹¹½¨ÁË»ùÓÚ¾¶Ïò»ùº¯Êý£¨RBF£©ºËµÄÖ§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£·ÖÀàÆ÷ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ÆÀ¹À£¬²¢ÔÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐÖÐ½øÐÐÑéÖ¤¡£\nÑÐ¾¿½á¹û\nÑÐ¾¿ÈËÈºÌØÕ÷£ºAS»¼¶ùÕûÌåÉö¹¦ÄÜ±£´æÁ¼ºÃ£¬Æ½¾ùeGFRÎª128¡À31 mL/min/1.73m2£¬ÓëÌÇÄò²¡ºÍRCAD¶ÓÁÐÏàµ±£¬¶øCAKUT¡¢OU¡¢ARPKDºÍÉöÏûºÄÖ¢¶ÓÁÐµÄeGFRÏÔÖø½ÏµÍ¡£AS¶ÓÁÐÖÐÄÐÐÔÕ¼¾ø¶ÔÓÅÊÆ£¨96%£©£¬·ûºÏ¸ß±ÈÀýXÁ¬Ëø¼²²¡µÄÌØÕ÷£¨57Àý»¼ÕßÖÐ46ÀýÎªXÁ¬Ëø£¬9ÀýÎª³£È¾É«ÌåÒþÐÔÒÅ´«AS£¬2ÀýÒÅ´«Ä£Ê½Î´¶¨Òå£©¡£\n·ÖÀàÆ÷µÄ¶¨Òå£ºÔÚ20,192ÖÖ¹Û²ìµ½µÄëÄÖÐ£¬±£ÁôÖÁÉÙÔÚ30%Ñù±¾ÖÐ¼ì³öµÄ7,451ÖÖëÄ½øÐÐ·ÖÎö¡£ÎÞ¼à¶½½µÎ¬ÏÔÊ¾ASÑù±¾ÓëÆäËû×é±ðÃ÷ÏÔ·ÖÀë¡£Í¨¹ýÅä¶Ô±È½Ï¼ø¶¨³ö151ÖÖ²îÒìëÄ£¬ÆäÖÐ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢£¨¶ÔÓ¦36ÖÖµ°°×ÖÊ£©£¬53ÖÖ£¨61%£©Îª½ºÔµ°°×ÑÜÉúëÄ£¬63ÖÖ£¨72%£©ÔÚASÖÐ·á¶ÈÔö¼Ó£¬24ÖÖ£¨28%£©·á¶È½µµÍ¡£ÔÚ½»²æÑéÖ¤µÄ·¢ÏÖ¶ÓÁÐÖÐ£¬·ÖÀàÆ÷±íÏÖ³öÓÅÒìÐÔÄÜ£¬AUC´ï0.997£¨95%CI 0.995¨C0.999£©£¬»ùÓÚYoudenÖ¸ÊýÈ·¶¨µÄ×î¼Ñ·ÖÀàãÐÖµÎª-0.196¡£\n·ÖÀàÆ÷µÄÑéÖ¤£º½«Ô¤¶¨ÒåãÐÖµÓ¦ÓÃÓÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐ£¬·ÖÀàÆ÷AUC´ï0.999£¨95%CI 0.997¨C1.000£©£¬ÁéÃô¶È100%£¬ÌØÒì¶È97.4%£¬×¼È·ÂÊ98.2%¡£AS»¼ÕßµÄ·ÖÀàÆ÷ÆÀ·ÖÏÔÖø¸ßÓÚÆäËûËùÓÐ¶ÓÁÐ¡£\nÈË¿ÚÑ§ºÍÁÙ´²±äÁ¿µÄÓ°Ïì£º¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬·ÖÀàÆ÷ÆÀ·ÖÔÚAS»¼ÕßÖÐÈÔ±£³Ö½Ï¸ßË®Æ½£¬Ð£ÕýºóAUCÎª0.918£¨95%CI 0.884¨C0.951£©£¬±íÃ÷ÆäÐÔÄÜ²¢·Ç½öÓÉÉö¹¦ÄÜ»òÈË¿ÚÑ§ÌØÕ÷²îÒìÇý¶¯¡£\n·ÖÀàÆ÷ËæÊ±¼ä±ä»¯µÄÆÀ¹À£º¶ÔÑéÖ¤¶ÓÁÐÖÐ17ÀýAS»¼ÕßµÄ×ÝÏòËæ·ÃÑù±¾·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ¸öÌåÄÚËæÊ±¼ä±£³ÖÒ»ÖÂ£¬ÇÒÊ¼ÖÕ¸ßÓÚÕï¶ÏãÐÖµ¡£ÖµµÃ×¢ÒâµÄÊÇ£¬Ò»ÃûÐ¯´ø°ëºÏ×ÓCOL4A5±äÒì£¨ÒâÒå²»Ã÷È·£©µÄ»¼ÕßÔÚËùÓÐËæ·ÃÊ±¼äµã¾ù±»·ÖÀàÎªÑôÐÔ¡£ÏßÐÔ»ìºÏÐ§Ó¦Ä£ÐÍÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÓë¼²²¡½øÕ¹£¨P=0.79£©¼°Ñª¹Ü½ôÕÅËØ×ª»»Ã¸ÒÖÖÆ¼Á£¨ACEi£©ÖÎÁÆ£¨P=0.66£©¾ùÎÞÏÔÖø¹ØÁª¡£\nÌÖÂÛÓë½áÂÛ\n±¾ÑÐ¾¿Ê×´Î¿ª·¢²¢ÑéÖ¤ÁËÓÃÓÚ¶ù¿ÆASÕï¶ÏµÄ¼²²¡ÌØÒìÐÔÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã·ÖÀàÆ÷ÔÚÑéÖ¤¶ÓÁÐÖÐÕ¹ÏÖ³ö×¿Ô½µÄÕï¶ÏÐÔÄÜ£¬·´Ó³ÁËÔçÆÚÂýÐÔÉöÔà²¡£¨CKD£©½×¶Î¶ù¿ÆASÏà¶ÔÓÚÆäËûÒìÖÊÐÔ¶ÓÁÐµÄÇ¿·Ö×Ó¶ÀÌØÐÔ¡£·ÖÀàÆ÷ÆÀ·ÖÔÚ×ÝÏòËæ·ÃÖÐ±£³ÖÎÈ¶¨£¬ÇÒÓë½øÕ¹×´Ì¬ÎÞÏÔÖø¹ØÁª£¬ÌáÊ¾¸ÃëÄ×éÑ§±êÖ¾Îï·´Ó³µÄÊÇÇ±ÔÚ¼²²¡ÉúÎïÑ§¶ø·Ç¶ÌÔÝµÄÁÙ´²²¨¶¯¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£ÕýºóÈÔ±£³ÖÇ¿¼ø±ðÐÔÄÜ£¬½øÒ»²½Ö¤ÊµÆäÎÈ½¡ÐÔ¡£\n´ÓÉúÎïÑ§½Ç¶È£¬·ÖÀàÆ÷ÖÐ°üº¬Ô´×Ô¶àÖÖµ°°×ÖÊµÄëÄ¶Î£¬°üÀ¨»ùµ×Ä¤Ïà¹ØIVÐÍ½ºÔÁ´ÒÔ¼°ÏËÎ¬×´ºÍÏ¸°ûÍâ»ùÖÊÏà¹Ø½ºÔ£¬ÕâÓëASµÄ²¡ÀíÉúÀí¸ß¶ÈÒ»ÖÂ¡£´ËÍâ£¬»¹°üº¬Ô´×ÔÄòµ÷½ÚËØ¡¢²¹ÌåC3ºÍ»ùµ×Ä¤ÌØÒìÐÔÁòËáÒÒõ£¸ÎËØµ°°×¾ÛÌÇµÄëÄ¶Î£¬ÌáÊ¾ÉöÐ¡¹ÜËðÉË¡¢Ñ×Ö¢¼¤»îºÍ»ùµ×Ä¤ÖØËÜÒ²¿ÉÄÜ²ÎÓë¶ù¿ÆASµÄ·Ö×ÓÌØÕ÷¡£±¾ÑÐ¾¿ÖÐ¶ù¿ÆAS±êÖ¾ÎïÓë¼ÈÍù±¨µÀµÄ³ÉÈËASÄòÒºëÄ×éÑ§±êÖ¾ÎïÖØµþ¼«ÉÙ£¬¿ÉÄÜÔÒò°üÀ¨ÄêÁäÏà¹ØµÄÄòÒºëÄ×é²îÒì¡¢ÒÅ´«·Ö²¼²îÒì£¨¶ù¿ÆÒÔCOL4A5±äÒìÎªÖ÷£¬³ÉÈËÒÔCOL4A3/COL4A4±äÒìÎªÖ÷£©ÒÔ¼°¼²²¡½×¶Î²îÒì£¨¶ùÍ¯¸ü·´Ó³Ô·¢ÐÔIVÐÍ½ºÔ¸Ä±ä£¬³ÉÈËÔò¸ü¶àÌåÏÖÏËÎ¬»¯ºÍ¹ã·ºÏ¸°ûÍâ»ùÖÊÖØËÜ£©¡£\nÑÐ¾¿½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖ×¼È·µÄÄòÒºëÄ×éÑ§·ÖÀàÆ÷£¬¿ÉÓÃÓÚ¶ù¿ÆASµÄÎÞ´´Õï¶Ï¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬ÓÈÆäÔÚÁÙ´²ÒÉËÆµ«·Ö×Ó¼ì²â½á¹û²»È·¶¨µÄ²¡ÀýÖÐ£¬ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£","image_url":null,"lang":"zh","published_at":"2026-09-28T00:14:13+00:00","fetched_at":"2026-09-28T02:15:13+00:00","status":"read","starred":0,"extract_state":"ok","summary_auto":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children\n        \n        \t\n            \t±à¼ÍÆ¼ö£º\n                \n                ¡¡¡¡ÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n                \n\t\t\t\t\n             \n            \n\t\t\t\n         \n        \n        ¡¡¡¡\nÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n·½·¨£º²ÉÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉµÄÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑéÖÐ57ÀýAS»¼¶ù£¨80.7%ÎªXÁ¬ËøÒÅ´«£¬Æ½¾ùÄêÁä10¡À4Ëê£¬Å®ÐÔÕ¼4%£¬Æ½¾ù¹ÀËãÉöÐ¡ÇòÂË¹ýÂÊ[eGFR]Îª128¡À31 mL/min/1.73 m2£©µÄ282·ÝÑù±¾£¬ÒÔ¼°À´×Ô¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxon¼ìÑé²¢¾Benjamini-HochbergÐ£Õý¼ø¶¨²îÒìëÄ£¬ÓÃÓÚ¹¹½¨Ö§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ºÍÔÚÑéÖ¤¶ÓÁÐÖÐµÄÓ¦ÓÃ½øÐÐÆÀ¹À¡£\n½á¹û£º¹²¼ø¶¨³ö151ÖÖ²îÒìëÄ¡£ÆäÖÐ87ÖÖëÄ¾ßÓÐÐòÁÐÐÅÏ¢²¢ÓÃÓÚ·ÖÀàÆ÷Éú³É£»60.9%Îª½ºÔµ°°×ÑÜÉúëÄ¡£ÔÚÑéÖ¤ÖÐ£¬¸Ã·ÖÀàÆ÷µÄÊÜÊÔÕß¹¤×÷ÌØÕ÷ÇúÏßÏÂÃæ»ý£¨AUC£©´ïµ½0.999£¨95%ÖÃÐÅÇø¼ä[CI] 0.997¨C1.000£©£¬ÁéÃô¶ÈÎª100%£¬ÌØÒì¶ÈÎª97.4%£¬×¼È·ÂÊÎª98.2%¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬ÆäÐÔÄÜÈÔÈ»½Ï¸ß£¨Ð£ÕýºóAUCÎª0.918£¬95% CI 0.884¨C0.951£©¡£×ÝÏò·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ³¤´ï3ÄêµÄËæ·ÃÆÚÄÚ±£³ÖÎÈ¶¨¡£\n½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖÓÃÓÚ¶ù¿ÆASÎÞ´´Õï¶ÏµÄ×¼È·ÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬²¢ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£\nÑÐ¾¿±³¾°ÓëÄ¿µÄ\nÒÅ´«ÐÔÉö²¡ÊÇ¶ùÍ¯ÖÕÄ©ÆÚÉö²¡µÄÖ÷ÒªÔÒòÖ®Ò»£¬ÆäÖÐAlport×ÛºÏÕ÷£¨AS£©ÊÇÓÉCOL4A3¡¢COL4A4»òCOL4A5»ùÒòÖÂ²¡ÐÔ±äÒìÒýÆðµÄÒÅ´«ÐÔÉöÔà¼²²¡£¬µ¼ÖÂIVÐÍ½ºÔ½á¹¹Òì³£ºÍ½øÐÐÐÔÉöÐ¡Çò»ùµ×Ä¤£¨GBM£©ËðÉË¡£ASÁÙ´²±íÏÖ¶àÑù£¬´Ó¹ÂÁ¢ÐÔÑªÄòµ½½øÐÐÐÔÂýÐÔÉöÔà²¡¡¢ÌýÁ¦É¥Ê§ºÍÑÛ²¿Òì³£²»µÈ¡£¶ùÍ¯ÆÚÔçÆÚÕï¶ÏÖÁ¹ØÖØÒª£¬ÒòÎªÊ¶±ðAS¿ÉÖ¸µ¼Ëæ·Ã²ßÂÔ¡¢¿ªÕ¹¼Ò×åÉ¸²é²¢¾¡ÔçÆô¶¯°üÀ¨ÉöËØ-Ñª¹Ü½ôÕÅËØÏµÍ³×è¶ÏÔÚÄÚµÄÉöÔà±£»¤ÖÎÁÆ£¬´Ó¶øÑÓ»º¼²²¡½øÕ¹¡£È»¶ø£¬¶ùÍ¯Õï¶ÏÃæÁÙÖî¶àÌôÕ½£ºÔçÆÚ±íÏÖÈç³ÖÐøÐÔ¾µÏÂÑªÄòÎª·ÇÌØÒìÐÔÖ¢×´£¬³£ÓëÆäËû¶ù¿ÆÉöÔà¼²²¡ÖØµþ£»¾¡¹Ü»ùÒò¼ì²âÒÑ³ÉÎªÕï¶ÏºËÐÄ£¬µ«ÏÖÓÐ²âÐò²ßÂÔÎÞ·¨¼ì³öËùÓÐÖÂ²¡±äÒì£¬Ô¼20%µÄÁÙ´²ÒÉËÆ»¼ÕßÎ´ÄÜÍ¨¹ý»ùÒò¼ì²âÈ·¶¨ÖÂ²¡±äÒì£¬ÔÒò°üÀ¨È«ÍâÏÔ×Ó×é²âÐòµÄ¼¼Êõ¾ÖÏÞ¡¢·Ç¾µä¼ô½Ó±äÒìµÄ¼ì²âÀ§ÄÑ¡¢Ç¶ºÏÌåÏÖÏóÒÔ¼°ÆäËûÉöÔà¼²²¡µ¼ÖÂµÄ±íÐÍÄ£ÄâµÈ¡£Éö»î¼ìËä¿ÉÌá¹©¶îÍâÕï¶ÏÐÅÏ¢£¬µ«ÆäÎªÇÖÈëÐÔ¼ì²é£¬ÇÒ¹â¾µÏÂ×éÖ¯Ñ§·¢ÏÖ¿ÉÄÜ·ÇÌØÒìÐÔ¡£ÕâÐ©¾ÖÏÞÐÔ´ÙÊ¹ÑÐ¾¿Õß¶Ô»ùÓÚÄòÒºµÄ·ÇÇÖÈëÐÔ·½·¨²úÉúÐËÈ¤£¬ÒÔÆÚÖ§³Ö¸üÔç¡¢¸ü±ã½ÝµÄAS¼ì²â¡£\nÑÐ¾¿·½·¨Óë½áÂÛ\nÑÐ¾¿ÈËÔ±ÀûÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑé£¨NCT01485978£©ÖÐ57ÀýAS»¼¶ùµÄ282·ÝÄòÒºÑù±¾£¬ÒÔ¼°À´×Ô¶à¸ö¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾×÷Îª±È½Ï¶ÓÁÐ£¬°üÀ¨ÏÈÌìÐÔÉöÔàºÍÄòÂ·»ûÐÎ£¨CAKUT£©¡¢¹£×èÐÔÄòÂ·²¡£¨OU£©¡¢³£È¾É«ÌåÒþÐÔÒÅ´«¶àÄÒÉö²¡£¨ARPKD£©¡¢ÉöÏûºÄÖ¢¡¢1ÐÍÌÇÄò²¡¡¢ÉöÄÒÖ×ºÍÌÇÄò²¡×ÛºÏÕ÷£¨RCAD£©»¼¶ù¼°½¡¿µ¶ùÍ¯¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxonÖÈºÍ¼ìÑé²¢¾Benjamini-Hochberg´íÎó·¢ÏÖÂÊ£¨FDR£©Ð£Õý½øÐÐÅä¶Ô±È½Ï£¬É¸Ñ¡³öÔÚËùÓÐ±È½ÏÖÐ·½ÏòÒ»ÖÂÇÒFDR<0.05µÄ²îÒìëÄ£¬×îÖÕÀûÓÃ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢µÄëÄ¶Î¹¹½¨ÁË»ùÓÚ¾¶Ïò»ùº¯Êý£¨RBF£©ºËµÄÖ§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£·ÖÀàÆ÷ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ÆÀ¹À£¬²¢ÔÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐÖÐ½øÐÐÑéÖ¤¡£\nÑÐ¾¿½á¹û\nÑÐ¾¿ÈËÈºÌØÕ÷£ºAS»¼¶ùÕûÌåÉö¹¦ÄÜ±£´æÁ¼ºÃ£¬Æ½¾ùeGFRÎª128¡À31 mL/min/1.73m2£¬ÓëÌÇÄò²¡ºÍRCAD¶ÓÁÐÏàµ±£¬¶øCAKUT¡¢OU¡¢ARPKDºÍÉöÏûºÄÖ¢¶ÓÁÐµÄeGFRÏÔÖø½ÏµÍ¡£AS¶ÓÁÐÖÐÄÐÐÔÕ¼¾ø¶ÔÓÅÊÆ£¨96%£©£¬·ûºÏ¸ß±ÈÀýXÁ¬Ëø¼²²¡µÄÌØÕ÷£¨57Àý»¼ÕßÖÐ46ÀýÎªXÁ¬Ëø£¬9ÀýÎª³£È¾É«ÌåÒþÐÔÒÅ´«AS£¬2ÀýÒÅ´«Ä£Ê½Î´¶¨Òå£©¡£\n·ÖÀàÆ÷µÄ¶¨Òå£ºÔÚ20,192ÖÖ¹Û²ìµ½µÄëÄÖÐ£¬±£ÁôÖÁÉÙÔÚ30%Ñù±¾ÖÐ¼ì³öµÄ7,451ÖÖëÄ½øÐÐ·ÖÎö¡£ÎÞ¼à¶½½µÎ¬ÏÔÊ¾ASÑù±¾ÓëÆäËû×é±ðÃ÷ÏÔ·ÖÀë¡£Í¨¹ýÅä¶Ô±È½Ï¼ø¶¨³ö151ÖÖ²îÒìëÄ£¬ÆäÖÐ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢£¨¶ÔÓ¦36ÖÖµ°°×ÖÊ£©£¬53ÖÖ£¨61%£©Îª½ºÔµ°°×ÑÜÉúëÄ£¬63ÖÖ£¨72%£©ÔÚASÖÐ·á¶ÈÔö¼Ó£¬24ÖÖ£¨28%£©·á¶È½µµÍ¡£ÔÚ½»²æÑéÖ¤µÄ·¢ÏÖ¶ÓÁÐÖÐ£¬·ÖÀàÆ÷±íÏÖ³öÓÅÒìÐÔÄÜ£¬AUC´ï0.997£¨95%CI 0.995¨C0.999£©£¬»ùÓÚYoudenÖ¸ÊýÈ·¶¨µÄ×î¼Ñ·ÖÀàãÐÖµÎª-0.196¡£\n·ÖÀàÆ÷µÄÑéÖ¤£º½«Ô¤¶¨ÒåãÐÖµÓ¦ÓÃÓÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐ£¬·ÖÀàÆ÷AUC´ï0.999£¨95%CI 0.997¨C1.000£©£¬ÁéÃô¶È100%£¬ÌØÒì¶È97.4%£¬×¼È·ÂÊ98.2%¡£AS»¼ÕßµÄ·ÖÀàÆ÷ÆÀ·ÖÏÔÖø¸ßÓÚÆäËûËùÓÐ¶ÓÁÐ¡£\nÈË¿ÚÑ§ºÍÁÙ´²±äÁ¿µÄÓ°Ïì£º¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬·ÖÀàÆ÷ÆÀ·ÖÔÚAS»¼ÕßÖÐÈÔ±£³Ö½Ï¸ßË®Æ½£¬Ð£ÕýºóAUCÎª0.918£¨95%CI 0.884¨C0.951£©£¬±íÃ÷ÆäÐÔÄÜ²¢·Ç½öÓÉÉö¹¦ÄÜ»òÈË¿ÚÑ§ÌØÕ÷²îÒìÇý¶¯¡£\n·ÖÀàÆ÷ËæÊ±¼ä±ä»¯µÄÆÀ¹À£º¶ÔÑéÖ¤¶ÓÁÐÖÐ17ÀýAS»¼ÕßµÄ×ÝÏòËæ·ÃÑù±¾·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ¸öÌåÄÚËæÊ±¼ä±£³ÖÒ»ÖÂ£¬ÇÒÊ¼ÖÕ¸ßÓÚÕï¶ÏãÐÖµ¡£ÖµµÃ×¢ÒâµÄÊÇ£¬Ò»ÃûÐ¯´ø°ëºÏ×ÓCOL4A5±äÒì£¨ÒâÒå²»Ã÷È·£©µÄ»¼ÕßÔÚËùÓÐËæ·ÃÊ±¼äµã¾ù±»·ÖÀàÎªÑôÐÔ¡£ÏßÐÔ»ìºÏÐ§Ó¦Ä£ÐÍÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÓë¼²²¡½øÕ¹£¨P=0.79£©¼°Ñª¹Ü½ôÕÅËØ×ª»»Ã¸ÒÖÖÆ¼Á£¨ACEi£©ÖÎÁÆ£¨P=0.66£©¾ùÎÞÏÔÖø¹ØÁª¡£\nÌÖÂÛÓë½áÂÛ\n±¾ÑÐ¾¿Ê×´Î¿ª·¢²¢ÑéÖ¤ÁËÓÃÓÚ¶ù¿ÆASÕï¶ÏµÄ¼²²¡ÌØÒìÐÔÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã·ÖÀàÆ÷ÔÚÑéÖ¤¶ÓÁÐÖÐÕ¹ÏÖ³ö×¿Ô½µÄÕï¶ÏÐÔÄÜ£¬·´Ó³ÁËÔçÆÚÂýÐÔÉöÔà²¡£¨CKD£©½×¶Î¶ù¿ÆASÏà¶ÔÓÚÆäËûÒìÖÊÐÔ¶ÓÁÐµÄÇ¿·Ö×Ó¶ÀÌØÐÔ¡£·ÖÀàÆ÷ÆÀ·ÖÔÚ×ÝÏòËæ·ÃÖÐ±£³ÖÎÈ¶¨£¬ÇÒÓë½øÕ¹×´Ì¬ÎÞÏÔÖø¹ØÁª£¬ÌáÊ¾¸ÃëÄ×éÑ§±êÖ¾Îï·´Ó³µÄÊÇÇ±ÔÚ¼²²¡ÉúÎïÑ§¶ø·Ç¶ÌÔÝµÄÁÙ´²²¨¶¯¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£ÕýºóÈÔ±£³ÖÇ¿¼ø±ðÐÔÄÜ£¬½øÒ»²½Ö¤ÊµÆäÎÈ½¡ÐÔ¡£\n´ÓÉúÎïÑ§½Ç¶È£¬·ÖÀàÆ÷ÖÐ°üº¬Ô´×Ô¶àÖÖµ°°×ÖÊµÄëÄ¶Î£¬°üÀ¨»ùµ×Ä¤Ïà¹ØIVÐÍ½ºÔÁ´ÒÔ¼°ÏËÎ¬×´ºÍÏ¸°ûÍâ»ùÖÊÏà¹Ø½ºÔ£¬ÕâÓëASµÄ²¡ÀíÉúÀí¸ß¶ÈÒ»ÖÂ¡£´ËÍâ£¬»¹°üº¬Ô´×ÔÄòµ÷½ÚËØ¡¢²¹ÌåC3ºÍ»ùµ×Ä¤ÌØÒìÐÔÁòËáÒÒõ£¸ÎËØµ°°×¾ÛÌÇµÄëÄ¶Î£¬ÌáÊ¾ÉöÐ¡¹ÜËðÉË¡¢Ñ×Ö¢¼¤»îºÍ»ùµ×Ä¤ÖØËÜÒ²¿ÉÄÜ²ÎÓë¶ù¿ÆASµÄ·Ö×ÓÌØÕ÷¡£±¾ÑÐ¾¿ÖÐ¶ù¿ÆAS±êÖ¾ÎïÓë¼ÈÍù±¨µÀµÄ³ÉÈËASÄòÒºëÄ×éÑ§±êÖ¾ÎïÖØµþ¼«ÉÙ£¬¿ÉÄÜÔÒò°üÀ¨ÄêÁäÏà¹ØµÄÄòÒºëÄ×é²îÒì¡¢ÒÅ´«·Ö²¼²îÒì£¨¶ù¿ÆÒÔCOL4A5±äÒìÎªÖ÷£¬³ÉÈËÒÔCOL4A3/COL4A4±äÒìÎªÖ÷£©ÒÔ¼°¼²²¡½×¶Î²îÒì£¨¶ùÍ¯¸ü·´Ó³Ô·¢ÐÔIVÐÍ½ºÔ¸Ä±ä£¬³ÉÈËÔò¸ü¶àÌåÏÖÏËÎ¬»¯ºÍ¹ã·ºÏ¸°ûÍâ»ùÖÊÖØËÜ£©¡£\nÑÐ¾¿½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖ×¼È·µÄÄòÒºëÄ×éÑ§·ÖÀàÆ÷£¬¿ÉÓÃÓÚ¶ù¿ÆASµÄÎÞ´´Õï¶Ï¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬ÓÈÆäÔÚÁÙ´²ÒÉËÆµ«·Ö×Ó¼ì²â½á¹û²»È·¶¨µÄ²¡ÀýÖÐ£¬ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£","cluster_id":null,"extract_retries":0,"extract_error":null,"contract_version":"news_item.v1","format_contract_version":"news_item_formats.v1","dedup_url":"https://www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 5705 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":5705,"summary_length":5705,"usable_text_length":5705,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":5705,"summary_length":5705}},"news_item":{"id":91531,"canonical_url":"https://www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","source_url":"https://www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","title":"儿童Alport综合征的无创诊断尿液肽组学标志物 - 生物通","source_name":"生物通","author":null,"published_at":"2026-09-28T00:14:13+00:00","locale":"zh","topic":"peptides","tags":[],"rss_summary":"<a href=\"https://news.google.com/rss/articles/CBMibEFVX3lxTE1BRjFZUE96T3FYU2xwc2FFOUVmMTRFZ2p1OUM0bndWRkFHTE9EU2NCeV8tRlE5cVdzXy02Mm5YU1o4cV9pc1JnamVTUnVEcUZXR3d5QXVTOUJMbndvN3IwMk1pYXNlQXUxN05PVQ?oc=5\" target=\"_blank\">儿童Alport综合征的无创诊断尿液肽组学标志物</a>&nbsp;&nbsp;<font color=\"#6f6f6f\">生物通</font>","full_text":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children\n        \n        \t\n            \t±à¼ÍÆ¼ö£º\n                \n                ¡¡¡¡ÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n                \n\t\t\t\t\n             \n            \n\t\t\t\n         \n        \n        ¡¡¡¡\nÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n·½·¨£º²ÉÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉµÄÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑéÖÐ57ÀýAS»¼¶ù£¨80.7%ÎªXÁ¬ËøÒÅ´«£¬Æ½¾ùÄêÁä10¡À4Ëê£¬Å®ÐÔÕ¼4%£¬Æ½¾ù¹ÀËãÉöÐ¡ÇòÂË¹ýÂÊ[eGFR]Îª128¡À31 mL/min/1.73 m2£©µÄ282·ÝÑù±¾£¬ÒÔ¼°À´×Ô¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxon¼ìÑé²¢¾Benjamini-HochbergÐ£Õý¼ø¶¨²îÒìëÄ£¬ÓÃÓÚ¹¹½¨Ö§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ºÍÔÚÑéÖ¤¶ÓÁÐÖÐµÄÓ¦ÓÃ½øÐÐÆÀ¹À¡£\n½á¹û£º¹²¼ø¶¨³ö151ÖÖ²îÒìëÄ¡£ÆäÖÐ87ÖÖëÄ¾ßÓÐÐòÁÐÐÅÏ¢²¢ÓÃÓÚ·ÖÀàÆ÷Éú³É£»60.9%Îª½ºÔµ°°×ÑÜÉúëÄ¡£ÔÚÑéÖ¤ÖÐ£¬¸Ã·ÖÀàÆ÷µÄÊÜÊÔÕß¹¤×÷ÌØÕ÷ÇúÏßÏÂÃæ»ý£¨AUC£©´ïµ½0.999£¨95%ÖÃÐÅÇø¼ä[CI] 0.997¨C1.000£©£¬ÁéÃô¶ÈÎª100%£¬ÌØÒì¶ÈÎª97.4%£¬×¼È·ÂÊÎª98.2%¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬ÆäÐÔÄÜÈÔÈ»½Ï¸ß£¨Ð£ÕýºóAUCÎª0.918£¬95% CI 0.884¨C0.951£©¡£×ÝÏò·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ³¤´ï3ÄêµÄËæ·ÃÆÚÄÚ±£³ÖÎÈ¶¨¡£\n½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖÓÃÓÚ¶ù¿ÆASÎÞ´´Õï¶ÏµÄ×¼È·ÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬²¢ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£\nÑÐ¾¿±³¾°ÓëÄ¿µÄ\nÒÅ´«ÐÔÉö²¡ÊÇ¶ùÍ¯ÖÕÄ©ÆÚÉö²¡µÄÖ÷ÒªÔÒòÖ®Ò»£¬ÆäÖÐAlport×ÛºÏÕ÷£¨AS£©ÊÇÓÉCOL4A3¡¢COL4A4»òCOL4A5»ùÒòÖÂ²¡ÐÔ±äÒìÒýÆðµÄÒÅ´«ÐÔÉöÔà¼²²¡£¬µ¼ÖÂIVÐÍ½ºÔ½á¹¹Òì³£ºÍ½øÐÐÐÔÉöÐ¡Çò»ùµ×Ä¤£¨GBM£©ËðÉË¡£ASÁÙ´²±íÏÖ¶àÑù£¬´Ó¹ÂÁ¢ÐÔÑªÄòµ½½øÐÐÐÔÂýÐÔÉöÔà²¡¡¢ÌýÁ¦É¥Ê§ºÍÑÛ²¿Òì³£²»µÈ¡£¶ùÍ¯ÆÚÔçÆÚÕï¶ÏÖÁ¹ØÖØÒª£¬ÒòÎªÊ¶±ðAS¿ÉÖ¸µ¼Ëæ·Ã²ßÂÔ¡¢¿ªÕ¹¼Ò×åÉ¸²é²¢¾¡ÔçÆô¶¯°üÀ¨ÉöËØ-Ñª¹Ü½ôÕÅËØÏµÍ³×è¶ÏÔÚÄÚµÄÉöÔà±£»¤ÖÎÁÆ£¬´Ó¶øÑÓ»º¼²²¡½øÕ¹¡£È»¶ø£¬¶ùÍ¯Õï¶ÏÃæÁÙÖî¶àÌôÕ½£ºÔçÆÚ±íÏÖÈç³ÖÐøÐÔ¾µÏÂÑªÄòÎª·ÇÌØÒìÐÔÖ¢×´£¬³£ÓëÆäËû¶ù¿ÆÉöÔà¼²²¡ÖØµþ£»¾¡¹Ü»ùÒò¼ì²âÒÑ³ÉÎªÕï¶ÏºËÐÄ£¬µ«ÏÖÓÐ²âÐò²ßÂÔÎÞ·¨¼ì³öËùÓÐÖÂ²¡±äÒì£¬Ô¼20%µÄÁÙ´²ÒÉËÆ»¼ÕßÎ´ÄÜÍ¨¹ý»ùÒò¼ì²âÈ·¶¨ÖÂ²¡±äÒì£¬ÔÒò°üÀ¨È«ÍâÏÔ×Ó×é²âÐòµÄ¼¼Êõ¾ÖÏÞ¡¢·Ç¾µä¼ô½Ó±äÒìµÄ¼ì²âÀ§ÄÑ¡¢Ç¶ºÏÌåÏÖÏóÒÔ¼°ÆäËûÉöÔà¼²²¡µ¼ÖÂµÄ±íÐÍÄ£ÄâµÈ¡£Éö»î¼ìËä¿ÉÌá¹©¶îÍâÕï¶ÏÐÅÏ¢£¬µ«ÆäÎªÇÖÈëÐÔ¼ì²é£¬ÇÒ¹â¾µÏÂ×éÖ¯Ñ§·¢ÏÖ¿ÉÄÜ·ÇÌØÒìÐÔ¡£ÕâÐ©¾ÖÏÞÐÔ´ÙÊ¹ÑÐ¾¿Õß¶Ô»ùÓÚÄòÒºµÄ·ÇÇÖÈëÐÔ·½·¨²úÉúÐËÈ¤£¬ÒÔÆÚÖ§³Ö¸üÔç¡¢¸ü±ã½ÝµÄAS¼ì²â¡£\nÑÐ¾¿·½·¨Óë½áÂÛ\nÑÐ¾¿ÈËÔ±ÀûÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑé£¨NCT01485978£©ÖÐ57ÀýAS»¼¶ùµÄ282·ÝÄòÒºÑù±¾£¬ÒÔ¼°À´×Ô¶à¸ö¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾×÷Îª±È½Ï¶ÓÁÐ£¬°üÀ¨ÏÈÌìÐÔÉöÔàºÍÄòÂ·»ûÐÎ£¨CAKUT£©¡¢¹£×èÐÔÄòÂ·²¡£¨OU£©¡¢³£È¾É«ÌåÒþÐÔÒÅ´«¶àÄÒÉö²¡£¨ARPKD£©¡¢ÉöÏûºÄÖ¢¡¢1ÐÍÌÇÄò²¡¡¢ÉöÄÒÖ×ºÍÌÇÄò²¡×ÛºÏÕ÷£¨RCAD£©»¼¶ù¼°½¡¿µ¶ùÍ¯¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxonÖÈºÍ¼ìÑé²¢¾Benjamini-Hochberg´íÎó·¢ÏÖÂÊ£¨FDR£©Ð£Õý½øÐÐÅä¶Ô±È½Ï£¬É¸Ñ¡³öÔÚËùÓÐ±È½ÏÖÐ·½ÏòÒ»ÖÂÇÒFDR<0.05µÄ²îÒìëÄ£¬×îÖÕÀûÓÃ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢µÄëÄ¶Î¹¹½¨ÁË»ùÓÚ¾¶Ïò»ùº¯Êý£¨RBF£©ºËµÄÖ§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£·ÖÀàÆ÷ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ÆÀ¹À£¬²¢ÔÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐÖÐ½øÐÐÑéÖ¤¡£\nÑÐ¾¿½á¹û\nÑÐ¾¿ÈËÈºÌØÕ÷£ºAS»¼¶ùÕûÌåÉö¹¦ÄÜ±£´æÁ¼ºÃ£¬Æ½¾ùeGFRÎª128¡À31 mL/min/1.73m2£¬ÓëÌÇÄò²¡ºÍRCAD¶ÓÁÐÏàµ±£¬¶øCAKUT¡¢OU¡¢ARPKDºÍÉöÏûºÄÖ¢¶ÓÁÐµÄeGFRÏÔÖø½ÏµÍ¡£AS¶ÓÁÐÖÐÄÐÐÔÕ¼¾ø¶ÔÓÅÊÆ£¨96%£©£¬·ûºÏ¸ß±ÈÀýXÁ¬Ëø¼²²¡µÄÌØÕ÷£¨57Àý»¼ÕßÖÐ46ÀýÎªXÁ¬Ëø£¬9ÀýÎª³£È¾É«ÌåÒþÐÔÒÅ´«AS£¬2ÀýÒÅ´«Ä£Ê½Î´¶¨Òå£©¡£\n·ÖÀàÆ÷µÄ¶¨Òå£ºÔÚ20,192ÖÖ¹Û²ìµ½µÄëÄÖÐ£¬±£ÁôÖÁÉÙÔÚ30%Ñù±¾ÖÐ¼ì³öµÄ7,451ÖÖëÄ½øÐÐ·ÖÎö¡£ÎÞ¼à¶½½µÎ¬ÏÔÊ¾ASÑù±¾ÓëÆäËû×é±ðÃ÷ÏÔ·ÖÀë¡£Í¨¹ýÅä¶Ô±È½Ï¼ø¶¨³ö151ÖÖ²îÒìëÄ£¬ÆäÖÐ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢£¨¶ÔÓ¦36ÖÖµ°°×ÖÊ£©£¬53ÖÖ£¨61%£©Îª½ºÔµ°°×ÑÜÉúëÄ£¬63ÖÖ£¨72%£©ÔÚASÖÐ·á¶ÈÔö¼Ó£¬24ÖÖ£¨28%£©·á¶È½µµÍ¡£ÔÚ½»²æÑéÖ¤µÄ·¢ÏÖ¶ÓÁÐÖÐ£¬·ÖÀàÆ÷±íÏÖ³öÓÅÒìÐÔÄÜ£¬AUC´ï0.997£¨95%CI 0.995¨C0.999£©£¬»ùÓÚYoudenÖ¸ÊýÈ·¶¨µÄ×î¼Ñ·ÖÀàãÐÖµÎª-0.196¡£\n·ÖÀàÆ÷µÄÑéÖ¤£º½«Ô¤¶¨ÒåãÐÖµÓ¦ÓÃÓÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐ£¬·ÖÀàÆ÷AUC´ï0.999£¨95%CI 0.997¨C1.000£©£¬ÁéÃô¶È100%£¬ÌØÒì¶È97.4%£¬×¼È·ÂÊ98.2%¡£AS»¼ÕßµÄ·ÖÀàÆ÷ÆÀ·ÖÏÔÖø¸ßÓÚÆäËûËùÓÐ¶ÓÁÐ¡£\nÈË¿ÚÑ§ºÍÁÙ´²±äÁ¿µÄÓ°Ïì£º¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬·ÖÀàÆ÷ÆÀ·ÖÔÚAS»¼ÕßÖÐÈÔ±£³Ö½Ï¸ßË®Æ½£¬Ð£ÕýºóAUCÎª0.918£¨95%CI 0.884¨C0.951£©£¬±íÃ÷ÆäÐÔÄÜ²¢·Ç½öÓÉÉö¹¦ÄÜ»òÈË¿ÚÑ§ÌØÕ÷²îÒìÇý¶¯¡£\n·ÖÀàÆ÷ËæÊ±¼ä±ä»¯µÄÆÀ¹À£º¶ÔÑéÖ¤¶ÓÁÐÖÐ17ÀýAS»¼ÕßµÄ×ÝÏòËæ·ÃÑù±¾·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ¸öÌåÄÚËæÊ±¼ä±£³ÖÒ»ÖÂ£¬ÇÒÊ¼ÖÕ¸ßÓÚÕï¶ÏãÐÖµ¡£ÖµµÃ×¢ÒâµÄÊÇ£¬Ò»ÃûÐ¯´ø°ëºÏ×ÓCOL4A5±äÒì£¨ÒâÒå²»Ã÷È·£©µÄ»¼ÕßÔÚËùÓÐËæ·ÃÊ±¼äµã¾ù±»·ÖÀàÎªÑôÐÔ¡£ÏßÐÔ»ìºÏÐ§Ó¦Ä£ÐÍÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÓë¼²²¡½øÕ¹£¨P=0.79£©¼°Ñª¹Ü½ôÕÅËØ×ª»»Ã¸ÒÖÖÆ¼Á£¨ACEi£©ÖÎÁÆ£¨P=0.66£©¾ùÎÞÏÔÖø¹ØÁª¡£\nÌÖÂÛÓë½áÂÛ\n±¾ÑÐ¾¿Ê×´Î¿ª·¢²¢ÑéÖ¤ÁËÓÃÓÚ¶ù¿ÆASÕï¶ÏµÄ¼²²¡ÌØÒìÐÔÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã·ÖÀàÆ÷ÔÚÑéÖ¤¶ÓÁÐÖÐÕ¹ÏÖ³ö×¿Ô½µÄÕï¶ÏÐÔÄÜ£¬·´Ó³ÁËÔçÆÚÂýÐÔÉöÔà²¡£¨CKD£©½×¶Î¶ù¿ÆASÏà¶ÔÓÚÆäËûÒìÖÊÐÔ¶ÓÁÐµÄÇ¿·Ö×Ó¶ÀÌØÐÔ¡£·ÖÀàÆ÷ÆÀ·ÖÔÚ×ÝÏòËæ·ÃÖÐ±£³ÖÎÈ¶¨£¬ÇÒÓë½øÕ¹×´Ì¬ÎÞÏÔÖø¹ØÁª£¬ÌáÊ¾¸ÃëÄ×éÑ§±êÖ¾Îï·´Ó³µÄÊÇÇ±ÔÚ¼²²¡ÉúÎïÑ§¶ø·Ç¶ÌÔÝµÄÁÙ´²²¨¶¯¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£ÕýºóÈÔ±£³ÖÇ¿¼ø±ðÐÔÄÜ£¬½øÒ»²½Ö¤ÊµÆäÎÈ½¡ÐÔ¡£\n´ÓÉúÎïÑ§½Ç¶È£¬·ÖÀàÆ÷ÖÐ°üº¬Ô´×Ô¶àÖÖµ°°×ÖÊµÄëÄ¶Î£¬°üÀ¨»ùµ×Ä¤Ïà¹ØIVÐÍ½ºÔÁ´ÒÔ¼°ÏËÎ¬×´ºÍÏ¸°ûÍâ»ùÖÊÏà¹Ø½ºÔ£¬ÕâÓëASµÄ²¡ÀíÉúÀí¸ß¶ÈÒ»ÖÂ¡£´ËÍâ£¬»¹°üº¬Ô´×ÔÄòµ÷½ÚËØ¡¢²¹ÌåC3ºÍ»ùµ×Ä¤ÌØÒìÐÔÁòËáÒÒõ£¸ÎËØµ°°×¾ÛÌÇµÄëÄ¶Î£¬ÌáÊ¾ÉöÐ¡¹ÜËðÉË¡¢Ñ×Ö¢¼¤»îºÍ»ùµ×Ä¤ÖØËÜÒ²¿ÉÄÜ²ÎÓë¶ù¿ÆASµÄ·Ö×ÓÌØÕ÷¡£±¾ÑÐ¾¿ÖÐ¶ù¿ÆAS±êÖ¾ÎïÓë¼ÈÍù±¨µÀµÄ³ÉÈËASÄòÒºëÄ×éÑ§±êÖ¾ÎïÖØµþ¼«ÉÙ£¬¿ÉÄÜÔÒò°üÀ¨ÄêÁäÏà¹ØµÄÄòÒºëÄ×é²îÒì¡¢ÒÅ´«·Ö²¼²îÒì£¨¶ù¿ÆÒÔCOL4A5±äÒìÎªÖ÷£¬³ÉÈËÒÔCOL4A3/COL4A4±äÒìÎªÖ÷£©ÒÔ¼°¼²²¡½×¶Î²îÒì£¨¶ùÍ¯¸ü·´Ó³Ô·¢ÐÔIVÐÍ½ºÔ¸Ä±ä£¬³ÉÈËÔò¸ü¶àÌåÏÖÏËÎ¬»¯ºÍ¹ã·ºÏ¸°ûÍâ»ùÖÊÖØËÜ£©¡£\nÑÐ¾¿½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖ×¼È·µÄÄòÒºëÄ×éÑ§·ÖÀàÆ÷£¬¿ÉÓÃÓÚ¶ù¿ÆASµÄÎÞ´´Õï¶Ï¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬ÓÈÆäÔÚÁÙ´²ÒÉËÆµ«·Ö×Ó¼ì²â½á¹û²»È·¶¨µÄ²¡ÀýÖÐ£¬ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£","excerpt":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children\n        \n        \t\n            \t±à¼ÍÆ¼ö£º\n                \n                ¡¡¡¡ÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n                \n\t\t\t\t\n             \n            \n\t\t\t\n         \n        \n        ¡¡¡¡\nÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n·½·¨£º²ÉÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉµÄÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑéÖÐ57ÀýAS»¼¶ù£¨80.7%ÎªXÁ¬ËøÒÅ´«£¬Æ½¾ùÄêÁä10¡À4Ëê£¬Å®ÐÔÕ¼4%£¬Æ½¾ù¹ÀËãÉöÐ¡ÇòÂË¹ýÂÊ[eGFR]Îª128¡À31 mL/min/1.73 m2£©µÄ282·ÝÑù±¾£¬ÒÔ¼°À´×Ô¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxon¼ìÑé²¢¾Benjamini-HochbergÐ£Õý¼ø¶¨²îÒìëÄ£¬ÓÃÓÚ¹¹½¨Ö§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ºÍÔÚÑéÖ¤¶ÓÁÐÖÐµÄÓ¦ÓÃ½øÐÐÆÀ¹À¡£\n½á¹û£º¹²¼ø¶¨³ö151ÖÖ²îÒìëÄ¡£ÆäÖÐ87ÖÖëÄ¾ßÓÐÐòÁÐÐÅÏ¢²¢ÓÃÓÚ·ÖÀàÆ÷Éú³É£»60.9%Îª½ºÔµ°°×ÑÜÉúëÄ¡£ÔÚÑéÖ¤ÖÐ£¬¸Ã·ÖÀàÆ÷µÄÊÜÊÔÕß¹¤×÷ÌØÕ÷ÇúÏßÏÂÃæ»ý£¨AUC£©´ïµ½0.999£¨95%ÖÃÐÅÇø¼ä[CI] 0.997¨C1.000£©£¬ÁéÃô¶ÈÎª100%£¬ÌØÒì¶ÈÎª97.4%£¬×¼È·ÂÊÎª98.2%¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬ÆäÐÔÄÜÈÔÈ»½Ï¸ß£¨Ð£ÕýºóAUCÎª0.918£¬95% CI 0.884¨C0.951£©¡£×ÝÏò·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ³¤´ï3ÄêµÄËæ·ÃÆÚÄÚ±£³ÖÎÈ¶¨¡£\n½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖÓÃÓÚ¶ù¿ÆASÎÞ´´Õï¶ÏµÄ×¼È·ÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬²¢ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£\nÑÐ¾¿±³¾°ÓëÄ¿µÄ\nÒÅ´«ÐÔÉö²¡ÊÇ¶ùÍ¯ÖÕÄ©ÆÚÉö²¡µÄÖ÷ÒªÔÒòÖ®Ò»£¬ÆäÖÐAlport×ÛºÏÕ÷£¨AS£©ÊÇÓÉCOL4A3¡¢COL4A4»òCOL4A5»ùÒòÖÂ²¡ÐÔ±äÒìÒýÆðµÄÒÅ´«ÐÔÉöÔà¼²²¡£¬µ¼ÖÂIVÐÍ½ºÔ½á¹¹Òì³£ºÍ½øÐÐÐÔÉöÐ¡Çò»ùµ×Ä¤£¨GBM£©ËðÉË¡£ASÁÙ´²±íÏÖ¶àÑù£¬´Ó¹ÂÁ¢ÐÔÑªÄòµ½½øÐÐÐÔÂýÐÔÉöÔà²¡¡¢ÌýÁ¦É¥Ê§ºÍÑÛ²¿Òì³£²»µÈ¡£¶ùÍ¯ÆÚÔçÆÚÕï¶ÏÖÁ¹ØÖØÒª£¬ÒòÎªÊ¶±ðAS¿ÉÖ¸µ¼Ëæ·Ã²ßÂÔ¡¢¿ªÕ¹¼Ò×åÉ¸²é²¢¾¡ÔçÆô¶¯°üÀ¨ÉöËØ-Ñª¹Ü½ôÕÅËØÏµÍ³×è¶ÏÔÚÄÚµÄÉöÔà±£»¤ÖÎÁÆ£¬´Ó¶øÑÓ»º¼²²¡½øÕ¹¡£È»¶ø£¬¶ùÍ¯Õï¶ÏÃæÁÙÖî¶àÌôÕ½£ºÔçÆÚ±íÏÖÈç³ÖÐøÐÔ¾µÏÂÑªÄòÎª·ÇÌØÒìÐÔÖ¢×´£¬³£ÓëÆäËû¶ù¿ÆÉöÔà¼²²¡ÖØµþ£»¾¡¹Ü»ùÒò¼ì²âÒÑ³ÉÎªÕï¶ÏºËÐÄ£¬µ«ÏÖÓÐ²âÐò²ßÂÔÎÞ·¨¼ì³öËùÓÐÖÂ²¡±äÒì£¬Ô¼20%µÄÁÙ´²ÒÉËÆ»¼ÕßÎ´ÄÜÍ¨¹ý»ùÒò¼ì²âÈ·¶¨ÖÂ²¡±äÒì£¬ÔÒò°üÀ¨È«ÍâÏÔ×Ó×é²âÐòµÄ¼¼Êõ¾ÖÏÞ¡¢·Ç¾µä¼ô½Ó±äÒìµÄ¼ì²âÀ§ÄÑ¡¢Ç¶ºÏÌåÏÖÏóÒÔ¼°ÆäËûÉöÔà¼²²¡µ¼ÖÂµÄ±íÐÍÄ£ÄâµÈ¡£Éö»î¼ìËä¿ÉÌá¹©¶îÍâÕï¶ÏÐÅÏ¢£¬µ«ÆäÎªÇÖÈëÐÔ¼ì²é£¬ÇÒ¹â¾µÏÂ×éÖ¯Ñ§·¢ÏÖ¿ÉÄÜ·ÇÌØÒìÐÔ¡£ÕâÐ©¾ÖÏÞÐÔ´ÙÊ¹ÑÐ¾¿Õß¶Ô»ùÓÚÄòÒºµÄ·ÇÇÖÈëÐÔ·½·¨²úÉúÐËÈ¤£¬ÒÔÆÚÖ§³Ö¸üÔç¡¢¸ü±ã½ÝµÄAS¼ì²â¡£\nÑÐ¾¿·½·¨Óë½áÂÛ\nÑÐ¾¿ÈËÔ±ÀûÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑé£¨NCT01485978£©ÖÐ57ÀýAS»¼¶ùµÄ282·ÝÄòÒºÑù±¾£¬ÒÔ¼°À´×Ô¶à¸ö¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾×÷Îª±È½Ï¶ÓÁÐ£¬°üÀ¨ÏÈÌìÐÔÉöÔàºÍÄòÂ·»ûÐÎ£¨CAKUT£©¡¢¹£×èÐÔÄòÂ·²¡£¨OU£©¡¢³£È¾É«ÌåÒþÐÔÒÅ´«¶àÄÒÉö²¡£¨ARPKD£©¡¢ÉöÏûºÄÖ¢¡¢1ÐÍÌÇÄò²¡¡¢ÉöÄÒÖ×ºÍÌÇÄò²¡×ÛºÏÕ÷£¨RCAD£©»¼¶ù¼°½¡¿µ¶ùÍ¯¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxonÖÈºÍ¼ìÑé²¢¾Benjamini-Hochberg´íÎó·¢ÏÖÂÊ£¨FDR£©Ð£Õý½øÐÐÅä¶Ô±È½Ï£¬É¸Ñ¡³öÔÚËùÓÐ±È½ÏÖÐ·½ÏòÒ»ÖÂÇÒFDR<0.05µÄ²îÒìëÄ£¬×îÖÕÀûÓÃ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢µÄëÄ¶Î¹¹½¨ÁË»ùÓÚ¾¶Ïò»ùº¯Êý£¨RBF£©ºËµÄÖ§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£·ÖÀàÆ÷ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ÆÀ¹À£¬²¢ÔÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐÖÐ½øÐÐÑéÖ¤¡£\nÑÐ¾¿½á¹û\nÑÐ¾¿ÈËÈºÌØÕ÷£ºAS»¼¶ùÕûÌåÉö¹¦ÄÜ±£´æÁ¼ºÃ£¬Æ½¾ùeGFRÎª128¡À31 mL/min/1.73m2£¬ÓëÌÇÄò²¡ºÍRCAD¶ÓÁÐÏàµ±£¬¶øCAKUT¡¢OU¡¢ARPKDºÍÉöÏûºÄÖ¢¶ÓÁÐµÄeGFRÏÔÖø½ÏµÍ¡£AS¶ÓÁÐÖÐÄÐÐÔÕ¼¾ø¶ÔÓÅÊÆ£¨96%£©£¬·ûºÏ¸ß±ÈÀýXÁ¬Ëø¼²²¡µÄÌØÕ÷£¨57Àý»¼ÕßÖÐ46ÀýÎªXÁ¬Ëø£¬9ÀýÎª³£È¾É«ÌåÒþÐÔÒÅ´«AS£¬2ÀýÒÅ´«Ä£Ê½Î´¶¨Òå£©¡£\n·ÖÀàÆ÷µÄ¶¨Òå£ºÔÚ20,192ÖÖ¹Û²ìµ½µÄëÄÖÐ£¬±£ÁôÖÁÉÙÔÚ30%Ñù±¾ÖÐ¼ì³öµÄ7,451ÖÖëÄ½øÐÐ·ÖÎö¡£ÎÞ¼à¶½½µÎ¬ÏÔÊ¾ASÑù±¾ÓëÆäËû×é±ðÃ÷ÏÔ·ÖÀë¡£Í¨¹ýÅä¶Ô±È½Ï¼ø¶¨³ö151ÖÖ²îÒìëÄ£¬ÆäÖÐ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢£¨¶ÔÓ¦36ÖÖµ°°×ÖÊ£©£¬53ÖÖ£¨61%£©Îª½ºÔµ°°×ÑÜÉúëÄ£¬63ÖÖ£¨72%£©ÔÚASÖÐ·á¶ÈÔö¼Ó£¬24ÖÖ£¨28%£©·á¶È½µµÍ¡£ÔÚ½»²æÑéÖ¤µÄ·¢ÏÖ¶ÓÁÐÖÐ£¬·ÖÀàÆ÷±íÏÖ³öÓÅÒìÐÔÄÜ£¬AUC´ï0.997£¨95%CI 0.995¨C0.999£©£¬»ùÓÚYoudenÖ¸ÊýÈ·¶¨µÄ×î¼Ñ·ÖÀàãÐÖµÎª-0.196¡£\n·ÖÀàÆ÷µÄÑéÖ¤£º½«Ô¤¶¨ÒåãÐÖµÓ¦ÓÃÓÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐ£¬·ÖÀàÆ÷AUC´ï0.999£¨95%CI 0.997¨C1.000£©£¬ÁéÃô¶È100%£¬ÌØÒì¶È97.4%£¬×¼È·ÂÊ98.2%¡£AS»¼ÕßµÄ·ÖÀàÆ÷ÆÀ·ÖÏÔÖø¸ßÓÚÆäËûËùÓÐ¶ÓÁÐ¡£\nÈË¿ÚÑ§ºÍÁÙ´²±äÁ¿µÄÓ°Ïì£º¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬·ÖÀàÆ÷ÆÀ·ÖÔÚAS»¼ÕßÖÐÈÔ±£³Ö½Ï¸ßË®Æ½£¬Ð£ÕýºóAUCÎª0.918£¨95%CI 0.884¨C0.951£©£¬±íÃ÷ÆäÐÔÄÜ²¢·Ç½öÓÉÉö¹¦ÄÜ»òÈË¿ÚÑ§ÌØÕ÷²îÒìÇý¶¯¡£\n·ÖÀàÆ÷ËæÊ±¼ä±ä»¯µÄÆÀ¹À£º¶ÔÑéÖ¤¶ÓÁÐÖÐ17ÀýAS»¼ÕßµÄ×ÝÏòËæ·ÃÑù±¾·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ¸öÌåÄÚËæÊ±¼ä±£³ÖÒ»ÖÂ£¬ÇÒÊ¼ÖÕ¸ßÓÚÕï¶ÏãÐÖµ¡£ÖµµÃ×¢ÒâµÄÊÇ£¬Ò»ÃûÐ¯´ø°ëºÏ×ÓCOL4A5±äÒì£¨ÒâÒå²»Ã÷È·£©µÄ»¼ÕßÔÚËùÓÐËæ·ÃÊ±¼äµã¾ù±»·ÖÀàÎªÑôÐÔ¡£ÏßÐÔ»ìºÏÐ§Ó¦Ä£ÐÍÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÓë¼²²¡½øÕ¹£¨P=0.79£©¼°Ñª¹Ü½ôÕÅËØ×ª»»Ã¸ÒÖÖÆ¼Á£¨ACEi£©ÖÎÁÆ£¨P=0.66£©¾ùÎÞÏÔÖø¹ØÁª¡£\nÌÖÂÛÓë½áÂÛ\n±¾ÑÐ¾¿Ê×´Î¿ª·¢²¢ÑéÖ¤ÁËÓÃÓÚ¶ù¿ÆASÕï¶ÏµÄ¼²²¡ÌØÒìÐÔÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã·ÖÀàÆ÷ÔÚÑéÖ¤¶ÓÁÐÖÐÕ¹ÏÖ³ö×¿Ô½µÄÕï¶ÏÐÔÄÜ£¬·´Ó³ÁËÔçÆÚÂýÐÔÉöÔà²¡£¨CKD£©½×¶Î¶ù¿ÆASÏà¶ÔÓÚÆäËûÒìÖÊÐÔ¶ÓÁÐµÄÇ¿·Ö×Ó¶ÀÌØÐÔ¡£·ÖÀàÆ÷ÆÀ·ÖÔÚ×ÝÏòËæ·ÃÖÐ±£³ÖÎÈ¶¨£¬ÇÒÓë½øÕ¹×´Ì¬ÎÞÏÔÖø¹ØÁª£¬ÌáÊ¾¸ÃëÄ×éÑ§±êÖ¾Îï·´Ó³µÄÊÇÇ±ÔÚ¼²²¡ÉúÎïÑ§¶ø·Ç¶ÌÔÝµÄÁÙ´²²¨¶¯¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£ÕýºóÈÔ±£³ÖÇ¿¼ø±ðÐÔÄÜ£¬½øÒ»²½Ö¤ÊµÆäÎÈ½¡ÐÔ¡£\n´ÓÉúÎïÑ§½Ç¶È£¬·ÖÀàÆ÷ÖÐ°üº¬Ô´×Ô¶àÖÖµ°°×ÖÊµÄëÄ¶Î£¬°üÀ¨»ùµ×Ä¤Ïà¹ØIVÐÍ½ºÔÁ´ÒÔ¼°ÏËÎ¬×´ºÍÏ¸°ûÍâ»ùÖÊÏà¹Ø½ºÔ£¬ÕâÓëASµÄ²¡ÀíÉúÀí¸ß¶ÈÒ»ÖÂ¡£´ËÍâ£¬»¹°üº¬Ô´×ÔÄòµ÷½ÚËØ¡¢²¹ÌåC3ºÍ»ùµ×Ä¤ÌØÒìÐÔÁòËáÒÒõ£¸ÎËØµ°°×¾ÛÌÇµÄëÄ¶Î£¬ÌáÊ¾ÉöÐ¡¹ÜËðÉË¡¢Ñ×Ö¢¼¤»îºÍ»ùµ×Ä¤ÖØËÜÒ²¿ÉÄÜ²ÎÓë¶ù¿ÆASµÄ·Ö×ÓÌØÕ÷¡£±¾ÑÐ¾¿ÖÐ¶ù¿ÆAS±êÖ¾ÎïÓë¼ÈÍù±¨µÀµÄ³ÉÈËASÄòÒºëÄ×éÑ§±êÖ¾ÎïÖØµþ¼«ÉÙ£¬¿ÉÄÜÔÒò°üÀ¨ÄêÁäÏà¹ØµÄÄòÒºëÄ×é²îÒì¡¢ÒÅ´«·Ö²¼²îÒì£¨¶ù¿ÆÒÔCOL4A5±äÒìÎªÖ÷£¬³ÉÈËÒÔCOL4A3/COL4A4±äÒìÎªÖ÷£©ÒÔ¼°¼²²¡½×¶Î²îÒì£¨¶ùÍ¯¸ü·´Ó³Ô·¢ÐÔIVÐÍ½ºÔ¸Ä±ä£¬³ÉÈËÔò¸ü¶àÌåÏÖÏËÎ¬»¯ºÍ¹ã·ºÏ¸°ûÍâ»ùÖÊÖØËÜ£©¡£\nÑÐ¾¿½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖ×¼È·µÄÄòÒºëÄ×éÑ§·ÖÀàÆ÷£¬¿ÉÓÃÓÚ¶ù¿ÆASµÄÎÞ´´Õï¶Ï¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬ÓÈÆäÔÚÁÙ´²ÒÉËÆµ«·Ö×Ó¼ì²â½á¹û²»È·¶¨µÄ²¡ÀýÖÐ£¬ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£","extraction":{"state":"ok","confidence":0.9,"error":null,"explanation":"High confidence: full text extraction produced 5705 characters.","diagnostics_url":"/api/diagnose?url=https%3A//www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 5705 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":5705,"summary_length":5705,"usable_text_length":5705,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":5705,"summary_length":5705}}},"display_formats":["compact","card","full","digest_section","json"]},"daily_stack_record":{"title":"儿童Alport综合征的无创诊断尿液肽组学标志物 - 生物通","url":"https://www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","summary":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children\n        \n        \t\n            \t±à¼ÍÆ¼ö£º\n                \n                ¡¡¡¡ÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n                \n\t\t\t\t\n             \n            \n\t\t\t\n         \n        \n        ¡¡¡¡\nÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n·½·¨£º²ÉÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉµÄÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑéÖÐ57ÀýAS»¼¶ù£¨80.7%ÎªXÁ¬ËøÒÅ´«£¬Æ½¾ùÄêÁä10¡À4Ëê£¬Å®ÐÔÕ¼4%£¬Æ½¾ù¹ÀËãÉöÐ¡ÇòÂË¹ýÂÊ[eGFR]Îª128¡À31 mL/min/1.73 m2£©µÄ282·ÝÑù±¾£¬ÒÔ¼°À´×Ô¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxon¼ìÑé²¢¾Benjamini-HochbergÐ£Õý¼ø¶¨²îÒìëÄ£¬ÓÃÓÚ¹¹½¨Ö§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ºÍÔÚÑéÖ¤¶ÓÁÐÖÐµÄÓ¦ÓÃ½øÐÐÆÀ¹À¡£\n½á¹û£º¹²¼ø¶¨³ö151ÖÖ²îÒìëÄ¡£ÆäÖÐ87ÖÖëÄ¾ßÓÐÐòÁÐÐÅÏ¢²¢ÓÃÓÚ·ÖÀàÆ÷Éú³É£»60.9%Îª½ºÔµ°°×ÑÜÉúëÄ¡£ÔÚÑéÖ¤ÖÐ£¬¸Ã·ÖÀàÆ÷µÄÊÜÊÔÕß¹¤×÷ÌØÕ÷ÇúÏßÏÂÃæ»ý£¨AUC£©´ïµ½0.999£¨95%ÖÃÐÅÇø¼ä[CI] 0.997¨C1.000£©£¬ÁéÃô¶ÈÎª100%£¬ÌØÒì¶ÈÎª97.4%£¬×¼È·ÂÊÎª98.2%¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬ÆäÐÔÄÜÈÔÈ»½Ï¸ß£¨Ð£ÕýºóAUCÎª0.918£¬95% CI 0.884¨C0.951£©¡£×ÝÏò·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ³¤´ï3ÄêµÄËæ·ÃÆÚÄÚ±£³ÖÎÈ¶¨¡£\n½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖÓÃÓÚ¶ù¿ÆASÎÞ´´Õï¶ÏµÄ×¼È·ÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬²¢ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£\nÑÐ¾¿±³¾°ÓëÄ¿µÄ\nÒÅ´«ÐÔÉö²¡ÊÇ¶ùÍ¯ÖÕÄ©ÆÚÉö²¡µÄÖ÷ÒªÔÒòÖ®Ò»£¬ÆäÖÐAlport×ÛºÏÕ÷£¨AS£©ÊÇÓÉCOL4A3¡¢COL4A4»òCOL4A5»ùÒòÖÂ²¡ÐÔ±äÒìÒýÆðµÄÒÅ´«ÐÔÉöÔà¼²²¡£¬µ¼ÖÂIVÐÍ½ºÔ½á¹¹Òì³£ºÍ½øÐÐÐÔÉöÐ¡Çò»ùµ×Ä¤£¨GBM£©ËðÉË¡£ASÁÙ´²±íÏÖ¶àÑù£¬´Ó¹ÂÁ¢ÐÔÑªÄòµ½½øÐÐÐÔÂýÐÔÉöÔà²¡¡¢ÌýÁ¦É¥Ê§ºÍÑÛ²¿Òì³£²»µÈ¡£¶ùÍ¯ÆÚÔçÆÚÕï¶ÏÖÁ¹ØÖØÒª£¬ÒòÎªÊ¶±ðAS¿ÉÖ¸µ¼Ëæ·Ã²ßÂÔ¡¢¿ªÕ¹¼Ò×åÉ¸²é²¢¾¡ÔçÆô¶¯°üÀ¨ÉöËØ-Ñª¹Ü½ôÕÅËØÏµÍ³×è¶ÏÔÚÄÚµÄÉöÔà±£»¤ÖÎÁÆ£¬´Ó¶øÑÓ»º¼²²¡½øÕ¹¡£È»¶ø£¬¶ùÍ¯Õï¶ÏÃæÁÙÖî¶àÌôÕ½£ºÔçÆÚ±íÏÖÈç³ÖÐøÐÔ¾µÏÂÑªÄòÎª·ÇÌØÒìÐÔÖ¢×´£¬³£ÓëÆäËû¶ù¿ÆÉöÔà¼²²¡ÖØµþ£»¾¡¹Ü»ùÒò¼ì²âÒÑ³ÉÎªÕï¶ÏºËÐÄ£¬µ«ÏÖÓÐ²âÐò²ßÂÔÎÞ·¨¼ì³öËùÓÐÖÂ²¡±äÒì£¬Ô¼20%µÄÁÙ´²ÒÉËÆ»¼ÕßÎ´ÄÜÍ¨¹ý»ùÒò¼ì²âÈ·¶¨ÖÂ²¡±äÒì£¬ÔÒò°üÀ¨È«ÍâÏÔ×Ó×é²âÐòµÄ¼¼Êõ¾ÖÏÞ¡¢·Ç¾µä¼ô½Ó±äÒìµÄ¼ì²âÀ§ÄÑ¡¢Ç¶ºÏÌåÏÖÏóÒÔ¼°ÆäËûÉöÔà¼²²¡µ¼ÖÂµÄ±íÐÍÄ£ÄâµÈ¡£Éö»î¼ìËä¿ÉÌá¹©¶îÍâÕï¶ÏÐÅÏ¢£¬µ«ÆäÎªÇÖÈëÐÔ¼ì²é£¬ÇÒ¹â¾µÏÂ×éÖ¯Ñ§·¢ÏÖ¿ÉÄÜ·ÇÌØÒìÐÔ¡£ÕâÐ©¾ÖÏÞÐÔ´ÙÊ¹ÑÐ¾¿Õß¶Ô»ùÓÚÄòÒºµÄ·ÇÇÖÈëÐÔ·½·¨²úÉúÐËÈ¤£¬ÒÔÆÚÖ§³Ö¸üÔç¡¢¸ü±ã½ÝµÄAS¼ì²â¡£\nÑÐ¾¿·½·¨Óë½áÂÛ\nÑÐ¾¿ÈËÔ±ÀûÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑé£¨NCT01485978£©ÖÐ57ÀýAS»¼¶ùµÄ282·ÝÄòÒºÑù±¾£¬ÒÔ¼°À´×Ô¶à¸ö¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾×÷Îª±È½Ï¶ÓÁÐ£¬°üÀ¨ÏÈÌìÐÔÉöÔàºÍÄòÂ·»ûÐÎ£¨CAKUT£©¡¢¹£×èÐÔÄòÂ·²¡£¨OU£©¡¢³£È¾É«ÌåÒþÐÔÒÅ´«¶àÄÒÉö²¡£¨ARPKD£©¡¢ÉöÏûºÄÖ¢¡¢1ÐÍÌÇÄò²¡¡¢ÉöÄÒÖ×ºÍÌÇÄò²¡×ÛºÏÕ÷£¨RCAD£©»¼¶ù¼°½¡¿µ¶ùÍ¯¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxonÖÈºÍ¼ìÑé²¢¾Benjamini-Hochberg´íÎó·¢ÏÖÂÊ£¨FDR£©Ð£Õý½øÐÐÅä¶Ô±È½Ï£¬É¸Ñ¡³öÔÚËùÓÐ±È½ÏÖÐ·½ÏòÒ»ÖÂÇÒFDR<0.05µÄ²îÒìëÄ£¬×îÖÕÀûÓÃ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢µÄëÄ¶Î¹¹½¨ÁË»ùÓÚ¾¶Ïò»ùº¯Êý£¨RBF£©ºËµÄÖ§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£·ÖÀàÆ÷ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ÆÀ¹À£¬²¢ÔÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐÖÐ½øÐÐÑéÖ¤¡£\nÑÐ¾¿½á¹û\nÑÐ¾¿ÈËÈºÌØÕ÷£ºAS»¼¶ùÕûÌåÉö¹¦ÄÜ±£´æÁ¼ºÃ£¬Æ½¾ùeGFRÎª128¡À31 mL/min/1.73m2£¬ÓëÌÇÄò²¡ºÍRCAD¶ÓÁÐÏàµ±£¬¶øCAKUT¡¢OU¡¢ARPKDºÍÉöÏûºÄÖ¢¶ÓÁÐµÄeGFRÏÔÖø½ÏµÍ¡£AS¶ÓÁÐÖÐÄÐÐÔÕ¼¾ø¶ÔÓÅÊÆ£¨96%£©£¬·ûºÏ¸ß±ÈÀýXÁ¬Ëø¼²²¡µÄÌØÕ÷£¨57Àý»¼ÕßÖÐ46ÀýÎªXÁ¬Ëø£¬9ÀýÎª³£È¾É«ÌåÒþÐÔÒÅ´«AS£¬2ÀýÒÅ´«Ä£Ê½Î´¶¨Òå£©¡£\n·ÖÀàÆ÷µÄ¶¨Òå£ºÔÚ20,192ÖÖ¹Û²ìµ½µÄëÄÖÐ£¬±£ÁôÖÁÉÙÔÚ30%Ñù±¾ÖÐ¼ì³öµÄ7,451ÖÖëÄ½øÐÐ·ÖÎö¡£ÎÞ¼à¶½½µÎ¬ÏÔÊ¾ASÑù±¾ÓëÆäËû×é±ðÃ÷ÏÔ·ÖÀë¡£Í¨¹ýÅä¶Ô±È½Ï¼ø¶¨³ö151ÖÖ²îÒìëÄ£¬ÆäÖÐ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢£¨¶ÔÓ¦36ÖÖµ°°×ÖÊ£©£¬53ÖÖ£¨61%£©Îª½ºÔµ°°×ÑÜÉúëÄ£¬63ÖÖ£¨72%£©ÔÚASÖÐ·á¶ÈÔö¼Ó£¬24ÖÖ£¨28%£©·á¶È½µµÍ¡£ÔÚ½»²æÑéÖ¤µÄ·¢ÏÖ¶ÓÁÐÖÐ£¬·ÖÀàÆ÷±íÏÖ³öÓÅÒìÐÔÄÜ£¬AUC´ï0.997£¨95%CI 0.995¨C0.999£©£¬»ùÓÚYoudenÖ¸ÊýÈ·¶¨µÄ×î¼Ñ·ÖÀàãÐÖµÎª-0.196¡£\n·ÖÀàÆ÷µÄÑéÖ¤£º½«Ô¤¶¨ÒåãÐÖµÓ¦ÓÃÓÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐ£¬·ÖÀàÆ÷AUC´ï0.999£¨95%CI 0.997¨C1.000£©£¬ÁéÃô¶È100%£¬ÌØÒì¶È97.4%£¬×¼È·ÂÊ98.2%¡£AS»¼ÕßµÄ·ÖÀàÆ÷ÆÀ·ÖÏÔÖø¸ßÓÚÆäËûËùÓÐ¶ÓÁÐ¡£\nÈË¿ÚÑ§ºÍÁÙ´²±äÁ¿µÄÓ°Ïì£º¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬·ÖÀàÆ÷ÆÀ·ÖÔÚAS»¼ÕßÖÐÈÔ±£³Ö½Ï¸ßË®Æ½£¬Ð£ÕýºóAUCÎª0.918£¨95%CI 0.884¨C0.951£©£¬±íÃ÷ÆäÐÔÄÜ²¢·Ç½öÓÉÉö¹¦ÄÜ»òÈË¿ÚÑ§ÌØÕ÷²îÒìÇý¶¯¡£\n·ÖÀàÆ÷ËæÊ±¼ä±ä»¯µÄÆÀ¹À£º¶ÔÑéÖ¤¶ÓÁÐÖÐ17ÀýAS»¼ÕßµÄ×ÝÏòËæ·ÃÑù±¾·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ¸öÌåÄÚËæÊ±¼ä±£³ÖÒ»ÖÂ£¬ÇÒÊ¼ÖÕ¸ßÓÚÕï¶ÏãÐÖµ¡£ÖµµÃ×¢ÒâµÄÊÇ£¬Ò»ÃûÐ¯´ø°ëºÏ×ÓCOL4A5±äÒì£¨ÒâÒå²»Ã÷È·£©µÄ»¼ÕßÔÚËùÓÐËæ·ÃÊ±¼äµã¾ù±»·ÖÀàÎªÑôÐÔ¡£ÏßÐÔ»ìºÏÐ§Ó¦Ä£ÐÍÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÓë¼²²¡½øÕ¹£¨P=0.79£©¼°Ñª¹Ü½ôÕÅËØ×ª»»Ã¸ÒÖÖÆ¼Á£¨ACEi£©ÖÎÁÆ£¨P=0.66£©¾ùÎÞÏÔÖø¹ØÁª¡£\nÌÖÂÛÓë½áÂÛ\n±¾ÑÐ¾¿Ê×´Î¿ª·¢²¢ÑéÖ¤ÁËÓÃÓÚ¶ù¿ÆASÕï¶ÏµÄ¼²²¡ÌØÒìÐÔÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã·ÖÀàÆ÷ÔÚÑéÖ¤¶ÓÁÐÖÐÕ¹ÏÖ³ö×¿Ô½µÄÕï¶ÏÐÔÄÜ£¬·´Ó³ÁËÔçÆÚÂýÐÔÉöÔà²¡£¨CKD£©½×¶Î¶ù¿ÆASÏà¶ÔÓÚÆäËûÒìÖÊÐÔ¶ÓÁÐµÄÇ¿·Ö×Ó¶ÀÌØÐÔ¡£·ÖÀàÆ÷ÆÀ·ÖÔÚ×ÝÏòËæ·ÃÖÐ±£³ÖÎÈ¶¨£¬ÇÒÓë½øÕ¹×´Ì¬ÎÞÏÔÖø¹ØÁª£¬ÌáÊ¾¸ÃëÄ×éÑ§±êÖ¾Îï·´Ó³µÄÊÇÇ±ÔÚ¼²²¡ÉúÎïÑ§¶ø·Ç¶ÌÔÝµÄÁÙ´²²¨¶¯¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£ÕýºóÈÔ±£³ÖÇ¿¼ø±ðÐÔÄÜ£¬½øÒ»²½Ö¤ÊµÆäÎÈ½¡ÐÔ¡£\n´ÓÉúÎïÑ§½Ç¶È£¬·ÖÀàÆ÷ÖÐ°üº¬Ô´×Ô¶àÖÖµ°°×ÖÊµÄëÄ¶Î£¬°üÀ¨»ùµ×Ä¤Ïà¹ØIVÐÍ½ºÔÁ´ÒÔ¼°ÏËÎ¬×´ºÍÏ¸°ûÍâ»ùÖÊÏà¹Ø½ºÔ£¬ÕâÓëASµÄ²¡ÀíÉúÀí¸ß¶ÈÒ»ÖÂ¡£´ËÍâ£¬»¹°üº¬Ô´×ÔÄòµ÷½ÚËØ¡¢²¹ÌåC3ºÍ»ùµ×Ä¤ÌØÒìÐÔÁòËáÒÒõ£¸ÎËØµ°°×¾ÛÌÇµÄëÄ¶Î£¬ÌáÊ¾ÉöÐ¡¹ÜËðÉË¡¢Ñ×Ö¢¼¤»îºÍ»ùµ×Ä¤ÖØËÜÒ²¿ÉÄÜ²ÎÓë¶ù¿ÆASµÄ·Ö×ÓÌØÕ÷¡£±¾ÑÐ¾¿ÖÐ¶ù¿ÆAS±êÖ¾ÎïÓë¼ÈÍù±¨µÀµÄ³ÉÈËASÄòÒºëÄ×éÑ§±êÖ¾ÎïÖØµþ¼«ÉÙ£¬¿ÉÄÜÔÒò°üÀ¨ÄêÁäÏà¹ØµÄÄòÒºëÄ×é²îÒì¡¢ÒÅ´«·Ö²¼²îÒì£¨¶ù¿ÆÒÔCOL4A5±äÒìÎªÖ÷£¬³ÉÈËÒÔCOL4A3/COL4A4±äÒìÎªÖ÷£©ÒÔ¼°¼²²¡½×¶Î²îÒì£¨¶ùÍ¯¸ü·´Ó³Ô·¢ÐÔIVÐÍ½ºÔ¸Ä±ä£¬³ÉÈËÔò¸ü¶àÌåÏÖÏËÎ¬»¯ºÍ¹ã·ºÏ¸°ûÍâ»ùÖÊÖØËÜ£©¡£\nÑÐ¾¿½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖ×¼È·µÄÄòÒºëÄ×éÑ§·ÖÀàÆ÷£¬¿ÉÓÃÓÚ¶ù¿ÆASµÄÎÞ´´Õï¶Ï¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬ÓÈÆäÔÚÁÙ´²ÒÉËÆµ«·Ö×Ó¼ì²â½á¹û²»È·¶¨µÄ²¡ÀýÖÐ£¬ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£","source":"生物通","date":"2026-09-28T00:14:13+00:00","content":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children\n        \n        \t\n            \t±à¼ÍÆ¼ö£º\n                \n                ¡¡¡¡ÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n                \n\t\t\t\t\n             \n            \n\t\t\t\n         \n        \n        ¡¡¡¡\nÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n·½·¨£º²ÉÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉµÄÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑéÖÐ57ÀýAS»¼¶ù£¨80.7%ÎªXÁ¬ËøÒÅ´«£¬Æ½¾ùÄêÁä10¡À4Ëê£¬Å®ÐÔÕ¼4%£¬Æ½¾ù¹ÀËãÉöÐ¡ÇòÂË¹ýÂÊ[eGFR]Îª128¡À31 mL/min/1.73 m2£©µÄ282·ÝÑù±¾£¬ÒÔ¼°À´×Ô¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxon¼ìÑé²¢¾Benjamini-HochbergÐ£Õý¼ø¶¨²îÒìëÄ£¬ÓÃÓÚ¹¹½¨Ö§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ºÍÔÚÑéÖ¤¶ÓÁÐÖÐµÄÓ¦ÓÃ½øÐÐÆÀ¹À¡£\n½á¹û£º¹²¼ø¶¨³ö151ÖÖ²îÒìëÄ¡£ÆäÖÐ87ÖÖëÄ¾ßÓÐÐòÁÐÐÅÏ¢²¢ÓÃÓÚ·ÖÀàÆ÷Éú³É£»60.9%Îª½ºÔµ°°×ÑÜÉúëÄ¡£ÔÚÑéÖ¤ÖÐ£¬¸Ã·ÖÀàÆ÷µÄÊÜÊÔÕß¹¤×÷ÌØÕ÷ÇúÏßÏÂÃæ»ý£¨AUC£©´ïµ½0.999£¨95%ÖÃÐÅÇø¼ä[CI] 0.997¨C1.000£©£¬ÁéÃô¶ÈÎª100%£¬ÌØÒì¶ÈÎª97.4%£¬×¼È·ÂÊÎª98.2%¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬ÆäÐÔÄÜÈÔÈ»½Ï¸ß£¨Ð£ÕýºóAUCÎª0.918£¬95% CI 0.884¨C0.951£©¡£×ÝÏò·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ³¤´ï3ÄêµÄËæ·ÃÆÚÄÚ±£³ÖÎÈ¶¨¡£\n½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖÓÃÓÚ¶ù¿ÆASÎÞ´´Õï¶ÏµÄ×¼È·ÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬²¢ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£\nÑÐ¾¿±³¾°ÓëÄ¿µÄ\nÒÅ´«ÐÔÉö²¡ÊÇ¶ùÍ¯ÖÕÄ©ÆÚÉö²¡µÄÖ÷ÒªÔÒòÖ®Ò»£¬ÆäÖÐAlport×ÛºÏÕ÷£¨AS£©ÊÇÓÉCOL4A3¡¢COL4A4»òCOL4A5»ùÒòÖÂ²¡ÐÔ±äÒìÒýÆðµÄÒÅ´«ÐÔÉöÔà¼²²¡£¬µ¼ÖÂIVÐÍ½ºÔ½á¹¹Òì³£ºÍ½øÐÐÐÔÉöÐ¡Çò»ùµ×Ä¤£¨GBM£©ËðÉË¡£ASÁÙ´²±íÏÖ¶àÑù£¬´Ó¹ÂÁ¢ÐÔÑªÄòµ½½øÐÐÐÔÂýÐÔÉöÔà²¡¡¢ÌýÁ¦É¥Ê§ºÍÑÛ²¿Òì³£²»µÈ¡£¶ùÍ¯ÆÚÔçÆÚÕï¶ÏÖÁ¹ØÖØÒª£¬ÒòÎªÊ¶±ðAS¿ÉÖ¸µ¼Ëæ·Ã²ßÂÔ¡¢¿ªÕ¹¼Ò×åÉ¸²é²¢¾¡ÔçÆô¶¯°üÀ¨ÉöËØ-Ñª¹Ü½ôÕÅËØÏµÍ³×è¶ÏÔÚÄÚµÄÉöÔà±£»¤ÖÎÁÆ£¬´Ó¶øÑÓ»º¼²²¡½øÕ¹¡£È»¶ø£¬¶ùÍ¯Õï¶ÏÃæÁÙÖî¶àÌôÕ½£ºÔçÆÚ±íÏÖÈç³ÖÐøÐÔ¾µÏÂÑªÄòÎª·ÇÌØÒìÐÔÖ¢×´£¬³£ÓëÆäËû¶ù¿ÆÉöÔà¼²²¡ÖØµþ£»¾¡¹Ü»ùÒò¼ì²âÒÑ³ÉÎªÕï¶ÏºËÐÄ£¬µ«ÏÖÓÐ²âÐò²ßÂÔÎÞ·¨¼ì³öËùÓÐÖÂ²¡±äÒì£¬Ô¼20%µÄÁÙ´²ÒÉËÆ»¼ÕßÎ´ÄÜÍ¨¹ý»ùÒò¼ì²âÈ·¶¨ÖÂ²¡±äÒì£¬ÔÒò°üÀ¨È«ÍâÏÔ×Ó×é²âÐòµÄ¼¼Êõ¾ÖÏÞ¡¢·Ç¾µä¼ô½Ó±äÒìµÄ¼ì²âÀ§ÄÑ¡¢Ç¶ºÏÌåÏÖÏóÒÔ¼°ÆäËûÉöÔà¼²²¡µ¼ÖÂµÄ±íÐÍÄ£ÄâµÈ¡£Éö»î¼ìËä¿ÉÌá¹©¶îÍâÕï¶ÏÐÅÏ¢£¬µ«ÆäÎªÇÖÈëÐÔ¼ì²é£¬ÇÒ¹â¾µÏÂ×éÖ¯Ñ§·¢ÏÖ¿ÉÄÜ·ÇÌØÒìÐÔ¡£ÕâÐ©¾ÖÏÞÐÔ´ÙÊ¹ÑÐ¾¿Õß¶Ô»ùÓÚÄòÒºµÄ·ÇÇÖÈëÐÔ·½·¨²úÉúÐËÈ¤£¬ÒÔÆÚÖ§³Ö¸üÔç¡¢¸ü±ã½ÝµÄAS¼ì²â¡£\nÑÐ¾¿·½·¨Óë½áÂÛ\nÑÐ¾¿ÈËÔ±ÀûÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑé£¨NCT01485978£©ÖÐ57ÀýAS»¼¶ùµÄ282·ÝÄòÒºÑù±¾£¬ÒÔ¼°À´×Ô¶à¸ö¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾×÷Îª±È½Ï¶ÓÁÐ£¬°üÀ¨ÏÈÌìÐÔÉöÔàºÍÄòÂ·»ûÐÎ£¨CAKUT£©¡¢¹£×èÐÔÄòÂ·²¡£¨OU£©¡¢³£È¾É«ÌåÒþÐÔÒÅ´«¶àÄÒÉö²¡£¨ARPKD£©¡¢ÉöÏûºÄÖ¢¡¢1ÐÍÌÇÄò²¡¡¢ÉöÄÒÖ×ºÍÌÇÄò²¡×ÛºÏÕ÷£¨RCAD£©»¼¶ù¼°½¡¿µ¶ùÍ¯¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxonÖÈºÍ¼ìÑé²¢¾Benjamini-Hochberg´íÎó·¢ÏÖÂÊ£¨FDR£©Ð£Õý½øÐÐÅä¶Ô±È½Ï£¬É¸Ñ¡³öÔÚËùÓÐ±È½ÏÖÐ·½ÏòÒ»ÖÂÇÒFDR<0.05µÄ²îÒìëÄ£¬×îÖÕÀûÓÃ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢µÄëÄ¶Î¹¹½¨ÁË»ùÓÚ¾¶Ïò»ùº¯Êý£¨RBF£©ºËµÄÖ§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£·ÖÀàÆ÷ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ÆÀ¹À£¬²¢ÔÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐÖÐ½øÐÐÑéÖ¤¡£\nÑÐ¾¿½á¹û\nÑÐ¾¿ÈËÈºÌØÕ÷£ºAS»¼¶ùÕûÌåÉö¹¦ÄÜ±£´æÁ¼ºÃ£¬Æ½¾ùeGFRÎª128¡À31 mL/min/1.73m2£¬ÓëÌÇÄò²¡ºÍRCAD¶ÓÁÐÏàµ±£¬¶øCAKUT¡¢OU¡¢ARPKDºÍÉöÏûºÄÖ¢¶ÓÁÐµÄeGFRÏÔÖø½ÏµÍ¡£AS¶ÓÁÐÖÐÄÐÐÔÕ¼¾ø¶ÔÓÅÊÆ£¨96%£©£¬·ûºÏ¸ß±ÈÀýXÁ¬Ëø¼²²¡µÄÌØÕ÷£¨57Àý»¼ÕßÖÐ46ÀýÎªXÁ¬Ëø£¬9ÀýÎª³£È¾É«ÌåÒþÐÔÒÅ´«AS£¬2ÀýÒÅ´«Ä£Ê½Î´¶¨Òå£©¡£\n·ÖÀàÆ÷µÄ¶¨Òå£ºÔÚ20,192ÖÖ¹Û²ìµ½µÄëÄÖÐ£¬±£ÁôÖÁÉÙÔÚ30%Ñù±¾ÖÐ¼ì³öµÄ7,451ÖÖëÄ½øÐÐ·ÖÎö¡£ÎÞ¼à¶½½µÎ¬ÏÔÊ¾ASÑù±¾ÓëÆäËû×é±ðÃ÷ÏÔ·ÖÀë¡£Í¨¹ýÅä¶Ô±È½Ï¼ø¶¨³ö151ÖÖ²îÒìëÄ£¬ÆäÖÐ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢£¨¶ÔÓ¦36ÖÖµ°°×ÖÊ£©£¬53ÖÖ£¨61%£©Îª½ºÔµ°°×ÑÜÉúëÄ£¬63ÖÖ£¨72%£©ÔÚASÖÐ·á¶ÈÔö¼Ó£¬24ÖÖ£¨28%£©·á¶È½µµÍ¡£ÔÚ½»²æÑéÖ¤µÄ·¢ÏÖ¶ÓÁÐÖÐ£¬·ÖÀàÆ÷±íÏÖ³öÓÅÒìÐÔÄÜ£¬AUC´ï0.997£¨95%CI 0.995¨C0.999£©£¬»ùÓÚYoudenÖ¸ÊýÈ·¶¨µÄ×î¼Ñ·ÖÀàãÐÖµÎª-0.196¡£\n·ÖÀàÆ÷µÄÑéÖ¤£º½«Ô¤¶¨ÒåãÐÖµÓ¦ÓÃÓÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐ£¬·ÖÀàÆ÷AUC´ï0.999£¨95%CI 0.997¨C1.000£©£¬ÁéÃô¶È100%£¬ÌØÒì¶È97.4%£¬×¼È·ÂÊ98.2%¡£AS»¼ÕßµÄ·ÖÀàÆ÷ÆÀ·ÖÏÔÖø¸ßÓÚÆäËûËùÓÐ¶ÓÁÐ¡£\nÈË¿ÚÑ§ºÍÁÙ´²±äÁ¿µÄÓ°Ïì£º¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬·ÖÀàÆ÷ÆÀ·ÖÔÚAS»¼ÕßÖÐÈÔ±£³Ö½Ï¸ßË®Æ½£¬Ð£ÕýºóAUCÎª0.918£¨95%CI 0.884¨C0.951£©£¬±íÃ÷ÆäÐÔÄÜ²¢·Ç½öÓÉÉö¹¦ÄÜ»òÈË¿ÚÑ§ÌØÕ÷²îÒìÇý¶¯¡£\n·ÖÀàÆ÷ËæÊ±¼ä±ä»¯µÄÆÀ¹À£º¶ÔÑéÖ¤¶ÓÁÐÖÐ17ÀýAS»¼ÕßµÄ×ÝÏòËæ·ÃÑù±¾·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ¸öÌåÄÚËæÊ±¼ä±£³ÖÒ»ÖÂ£¬ÇÒÊ¼ÖÕ¸ßÓÚÕï¶ÏãÐÖµ¡£ÖµµÃ×¢ÒâµÄÊÇ£¬Ò»ÃûÐ¯´ø°ëºÏ×ÓCOL4A5±äÒì£¨ÒâÒå²»Ã÷È·£©µÄ»¼ÕßÔÚËùÓÐËæ·ÃÊ±¼äµã¾ù±»·ÖÀàÎªÑôÐÔ¡£ÏßÐÔ»ìºÏÐ§Ó¦Ä£ÐÍÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÓë¼²²¡½øÕ¹£¨P=0.79£©¼°Ñª¹Ü½ôÕÅËØ×ª»»Ã¸ÒÖÖÆ¼Á£¨ACEi£©ÖÎÁÆ£¨P=0.66£©¾ùÎÞÏÔÖø¹ØÁª¡£\nÌÖÂÛÓë½áÂÛ\n±¾ÑÐ¾¿Ê×´Î¿ª·¢²¢ÑéÖ¤ÁËÓÃÓÚ¶ù¿ÆASÕï¶ÏµÄ¼²²¡ÌØÒìÐÔÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã·ÖÀàÆ÷ÔÚÑéÖ¤¶ÓÁÐÖÐÕ¹ÏÖ³ö×¿Ô½µÄÕï¶ÏÐÔÄÜ£¬·´Ó³ÁËÔçÆÚÂýÐÔÉöÔà²¡£¨CKD£©½×¶Î¶ù¿ÆASÏà¶ÔÓÚÆäËûÒìÖÊÐÔ¶ÓÁÐµÄÇ¿·Ö×Ó¶ÀÌØÐÔ¡£·ÖÀàÆ÷ÆÀ·ÖÔÚ×ÝÏòËæ·ÃÖÐ±£³ÖÎÈ¶¨£¬ÇÒÓë½øÕ¹×´Ì¬ÎÞÏÔÖø¹ØÁª£¬ÌáÊ¾¸ÃëÄ×éÑ§±êÖ¾Îï·´Ó³µÄÊÇÇ±ÔÚ¼²²¡ÉúÎïÑ§¶ø·Ç¶ÌÔÝµÄÁÙ´²²¨¶¯¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£ÕýºóÈÔ±£³ÖÇ¿¼ø±ðÐÔÄÜ£¬½øÒ»²½Ö¤ÊµÆäÎÈ½¡ÐÔ¡£\n´ÓÉúÎïÑ§½Ç¶È£¬·ÖÀàÆ÷ÖÐ°üº¬Ô´×Ô¶àÖÖµ°°×ÖÊµÄëÄ¶Î£¬°üÀ¨»ùµ×Ä¤Ïà¹ØIVÐÍ½ºÔÁ´ÒÔ¼°ÏËÎ¬×´ºÍÏ¸°ûÍâ»ùÖÊÏà¹Ø½ºÔ£¬ÕâÓëASµÄ²¡ÀíÉúÀí¸ß¶ÈÒ»ÖÂ¡£´ËÍâ£¬»¹°üº¬Ô´×ÔÄòµ÷½ÚËØ¡¢²¹ÌåC3ºÍ»ùµ×Ä¤ÌØÒìÐÔÁòËáÒÒõ£¸ÎËØµ°°×¾ÛÌÇµÄëÄ¶Î£¬ÌáÊ¾ÉöÐ¡¹ÜËðÉË¡¢Ñ×Ö¢¼¤»îºÍ»ùµ×Ä¤ÖØËÜÒ²¿ÉÄÜ²ÎÓë¶ù¿ÆASµÄ·Ö×ÓÌØÕ÷¡£±¾ÑÐ¾¿ÖÐ¶ù¿ÆAS±êÖ¾ÎïÓë¼ÈÍù±¨µÀµÄ³ÉÈËASÄòÒºëÄ×éÑ§±êÖ¾ÎïÖØµþ¼«ÉÙ£¬¿ÉÄÜÔÒò°üÀ¨ÄêÁäÏà¹ØµÄÄòÒºëÄ×é²îÒì¡¢ÒÅ´«·Ö²¼²îÒì£¨¶ù¿ÆÒÔCOL4A5±äÒìÎªÖ÷£¬³ÉÈËÒÔCOL4A3/COL4A4±äÒìÎªÖ÷£©ÒÔ¼°¼²²¡½×¶Î²îÒì£¨¶ùÍ¯¸ü·´Ó³Ô·¢ÐÔIVÐÍ½ºÔ¸Ä±ä£¬³ÉÈËÔò¸ü¶àÌåÏÖÏËÎ¬»¯ºÍ¹ã·ºÏ¸°ûÍâ»ùÖÊÖØËÜ£©¡£\nÑÐ¾¿½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖ×¼È·µÄÄòÒºëÄ×éÑ§·ÖÀàÆ÷£¬¿ÉÓÃÓÚ¶ù¿ÆASµÄÎÞ´´Õï¶Ï¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬ÓÈÆäÔÚÁÙ´²ÒÉËÆµ«·Ö×Ó¼ì²â½á¹û²»È·¶¨µÄ²¡ÀýÖÐ£¬ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£","confidence":0.9,"diagnostics_url":"/api/diagnose?url=https%3A//www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","quality_bucket":"high","failure_kind":"none","retryable":false,"quality_reason":"High confidence: full text extraction produced 5705 characters.","quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 5705 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":5705,"summary_length":5705,"usable_text_length":5705,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":5705,"summary_length":5705}},"tags":[]},"fallback_formats":["markdown","json","html"],"actions":{"read":"/item/91531","export_markdown":"/api/items/91531/export?format=markdown","export_json":"/api/items/91531/export?format=json","diagnose":"/api/diagnose?url=https%3A//www.ebiotrade.com/newsf/2026-9/20260928000348291.htm"},"formats":{"full":{"id":91531,"title":"儿童Alport综合征的无创诊断尿液肽组学标志物 - 生物通","url":"https://www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","source":"生物通","author":null,"published_at":"2026-09-28T00:14:13+00:00","locale":"zh","topic":"peptides","tags":[],"excerpt":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children\n        \n        \t\n            \t±à¼ÍÆ¼ö£º\n                \n                ¡¡¡¡ÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n                \n\t\t\t\t\n             \n            \n\t\t\t\n         \n        \n        ¡¡¡¡\nÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n·½·¨£º²ÉÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉµÄÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑéÖÐ57ÀýAS»¼¶ù£¨80.7%ÎªXÁ¬ËøÒÅ´«£¬Æ½¾ùÄêÁä10¡À4Ëê£¬Å®ÐÔÕ¼4%£¬Æ½¾ù¹ÀËãÉöÐ¡ÇòÂË¹ýÂÊ[eGFR]Îª128¡À31 mL/min/1.73 m2£©µÄ282·ÝÑù±¾£¬ÒÔ¼°À´×Ô¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxon¼ìÑé²¢¾Benjamini-HochbergÐ£Õý¼ø¶¨²îÒìëÄ£¬ÓÃÓÚ¹¹½¨Ö§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ºÍÔÚÑéÖ¤¶ÓÁÐÖÐµÄÓ¦ÓÃ½øÐÐÆÀ¹À¡£\n½á¹û£º¹²¼ø¶¨³ö151ÖÖ²îÒìëÄ¡£ÆäÖÐ87ÖÖëÄ¾ßÓÐÐòÁÐÐÅÏ¢²¢ÓÃÓÚ·ÖÀàÆ÷Éú³É£»60.9%Îª½ºÔµ°°×ÑÜÉúëÄ¡£ÔÚÑéÖ¤ÖÐ£¬¸Ã·ÖÀàÆ÷µÄÊÜÊÔÕß¹¤×÷ÌØÕ÷ÇúÏßÏÂÃæ»ý£¨AUC£©´ïµ½0.999£¨95%ÖÃÐÅÇø¼ä[CI] 0.997¨C1.000£©£¬ÁéÃô¶ÈÎª100%£¬ÌØÒì¶ÈÎª97.4%£¬×¼È·ÂÊÎª98.2%¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬ÆäÐÔÄÜÈÔÈ»½Ï¸ß£¨Ð£ÕýºóAUCÎª0.918£¬95% CI 0.884¨C0.951£©¡£×ÝÏò·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ³¤´ï3ÄêµÄËæ·ÃÆÚÄÚ±£³ÖÎÈ¶¨¡£\n½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖÓÃÓÚ¶ù¿ÆASÎÞ´´Õï¶ÏµÄ×¼È·ÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬²¢ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£\nÑÐ¾¿±³¾°ÓëÄ¿µÄ\nÒÅ´«ÐÔÉö²¡ÊÇ¶ùÍ¯ÖÕÄ©ÆÚÉö²¡µÄÖ÷ÒªÔÒòÖ®Ò»£¬ÆäÖÐAlport×ÛºÏÕ÷£¨AS£©ÊÇÓÉCOL4A3¡¢COL4A4»òCOL4A5»ùÒòÖÂ²¡ÐÔ±äÒìÒýÆðµÄÒÅ´«ÐÔÉöÔà¼²²¡£¬µ¼ÖÂIVÐÍ½ºÔ½á¹¹Òì³£ºÍ½øÐÐÐÔÉöÐ¡Çò»ùµ×Ä¤£¨GBM£©ËðÉË¡£ASÁÙ´²±íÏÖ¶àÑù£¬´Ó¹ÂÁ¢ÐÔÑªÄòµ½½øÐÐÐÔÂýÐÔÉöÔà²¡¡¢ÌýÁ¦É¥Ê§ºÍÑÛ²¿Òì³£²»µÈ¡£¶ùÍ¯ÆÚÔçÆÚÕï¶ÏÖÁ¹ØÖØÒª£¬ÒòÎªÊ¶±ðAS¿ÉÖ¸µ¼Ëæ·Ã²ßÂÔ¡¢¿ªÕ¹¼Ò×åÉ¸²é²¢¾¡ÔçÆô¶¯°üÀ¨ÉöËØ-Ñª¹Ü½ôÕÅËØÏµÍ³×è¶ÏÔÚÄÚµÄÉöÔà±£»¤ÖÎÁÆ£¬´Ó¶øÑÓ»º¼²²¡½øÕ¹¡£È»¶ø£¬¶ùÍ¯Õï¶ÏÃæÁÙÖî¶àÌôÕ½£ºÔçÆÚ±íÏÖÈç³ÖÐøÐÔ¾µÏÂÑªÄòÎª·ÇÌØÒìÐÔÖ¢×´£¬³£ÓëÆäËû¶ù¿ÆÉöÔà¼²²¡ÖØµþ£»¾¡¹Ü»ùÒò¼ì²âÒÑ³ÉÎªÕï¶ÏºËÐÄ£¬µ«ÏÖÓÐ²âÐò²ßÂÔÎÞ·¨¼ì³öËùÓÐÖÂ²¡±äÒì£¬Ô¼20%µÄÁÙ´²ÒÉËÆ»¼ÕßÎ´ÄÜÍ¨¹ý»ùÒò¼ì²âÈ·¶¨ÖÂ²¡±äÒì£¬ÔÒò°üÀ¨È«ÍâÏÔ×Ó×é²âÐòµÄ¼¼Êõ¾ÖÏÞ¡¢·Ç¾µä¼ô½Ó±äÒìµÄ¼ì²âÀ§ÄÑ¡¢Ç¶ºÏÌåÏÖÏóÒÔ¼°ÆäËûÉöÔà¼²²¡µ¼ÖÂµÄ±íÐÍÄ£ÄâµÈ¡£Éö»î¼ìËä¿ÉÌá¹©¶îÍâÕï¶ÏÐÅÏ¢£¬µ«ÆäÎªÇÖÈëÐÔ¼ì²é£¬ÇÒ¹â¾µÏÂ×éÖ¯Ñ§·¢ÏÖ¿ÉÄÜ·ÇÌØÒìÐÔ¡£ÕâÐ©¾ÖÏÞÐÔ´ÙÊ¹ÑÐ¾¿Õß¶Ô»ùÓÚÄòÒºµÄ·ÇÇÖÈëÐÔ·½·¨²úÉúÐËÈ¤£¬ÒÔÆÚÖ§³Ö¸üÔç¡¢¸ü±ã½ÝµÄAS¼ì²â¡£\nÑÐ¾¿·½·¨Óë½áÂÛ\nÑÐ¾¿ÈËÔ±ÀûÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑé£¨NCT01485978£©ÖÐ57ÀýAS»¼¶ùµÄ282·ÝÄòÒºÑù±¾£¬ÒÔ¼°À´×Ô¶à¸ö¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾×÷Îª±È½Ï¶ÓÁÐ£¬°üÀ¨ÏÈÌìÐÔÉöÔàºÍÄòÂ·»ûÐÎ£¨CAKUT£©¡¢¹£×èÐÔÄòÂ·²¡£¨OU£©¡¢³£È¾É«ÌåÒþÐÔÒÅ´«¶àÄÒÉö²¡£¨ARPKD£©¡¢ÉöÏûºÄÖ¢¡¢1ÐÍÌÇÄò²¡¡¢ÉöÄÒÖ×ºÍÌÇÄò²¡×ÛºÏÕ÷£¨RCAD£©»¼¶ù¼°½¡¿µ¶ùÍ¯¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxonÖÈºÍ¼ìÑé²¢¾Benjamini-Hochberg´íÎó·¢ÏÖÂÊ£¨FDR£©Ð£Õý½øÐÐÅä¶Ô±È½Ï£¬É¸Ñ¡³öÔÚËùÓÐ±È½ÏÖÐ·½ÏòÒ»ÖÂÇÒFDR<0.05µÄ²îÒìëÄ£¬×îÖÕÀûÓÃ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢µÄëÄ¶Î¹¹½¨ÁË»ùÓÚ¾¶Ïò»ùº¯Êý£¨RBF£©ºËµÄÖ§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£·ÖÀàÆ÷ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ÆÀ¹À£¬²¢ÔÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐÖÐ½øÐÐÑéÖ¤¡£\nÑÐ¾¿½á¹û\nÑÐ¾¿ÈËÈºÌØÕ÷£ºAS»¼¶ùÕûÌåÉö¹¦ÄÜ±£´æÁ¼ºÃ£¬Æ½¾ùeGFRÎª128¡À31 mL/min/1.73m2£¬ÓëÌÇÄò²¡ºÍRCAD¶ÓÁÐÏàµ±£¬¶øCAKUT¡¢OU¡¢ARPKDºÍÉöÏûºÄÖ¢¶ÓÁÐµÄeGFRÏÔÖø½ÏµÍ¡£AS¶ÓÁÐÖÐÄÐÐÔÕ¼¾ø¶ÔÓÅÊÆ£¨96%£©£¬·ûºÏ¸ß±ÈÀýXÁ¬Ëø¼²²¡µÄÌØÕ÷£¨57Àý»¼ÕßÖÐ46ÀýÎªXÁ¬Ëø£¬9ÀýÎª³£È¾É«ÌåÒþÐÔÒÅ´«AS£¬2ÀýÒÅ´«Ä£Ê½Î´¶¨Òå£©¡£\n·ÖÀàÆ÷µÄ¶¨Òå£ºÔÚ20,192ÖÖ¹Û²ìµ½µÄëÄÖÐ£¬±£ÁôÖÁÉÙÔÚ30%Ñù±¾ÖÐ¼ì³öµÄ7,451ÖÖëÄ½øÐÐ·ÖÎö¡£ÎÞ¼à¶½½µÎ¬ÏÔÊ¾ASÑù±¾ÓëÆäËû×é±ðÃ÷ÏÔ·ÖÀë¡£Í¨¹ýÅä¶Ô±È½Ï¼ø¶¨³ö151ÖÖ²îÒìëÄ£¬ÆäÖÐ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢£¨¶ÔÓ¦36ÖÖµ°°×ÖÊ£©£¬53ÖÖ£¨61%£©Îª½ºÔµ°°×ÑÜÉúëÄ£¬63ÖÖ£¨72%£©ÔÚASÖÐ·á¶ÈÔö¼Ó£¬24ÖÖ£¨28%£©·á¶È½µµÍ¡£ÔÚ½»²æÑéÖ¤µÄ·¢ÏÖ¶ÓÁÐÖÐ£¬·ÖÀàÆ÷±íÏÖ³öÓÅÒìÐÔÄÜ£¬AUC´ï0.997£¨95%CI 0.995¨C0.999£©£¬»ùÓÚYoudenÖ¸ÊýÈ·¶¨µÄ×î¼Ñ·ÖÀàãÐÖµÎª-0.196¡£\n·ÖÀàÆ÷µÄÑéÖ¤£º½«Ô¤¶¨ÒåãÐÖµÓ¦ÓÃÓÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐ£¬·ÖÀàÆ÷AUC´ï0.999£¨95%CI 0.997¨C1.000£©£¬ÁéÃô¶È100%£¬ÌØÒì¶È97.4%£¬×¼È·ÂÊ98.2%¡£AS»¼ÕßµÄ·ÖÀàÆ÷ÆÀ·ÖÏÔÖø¸ßÓÚÆäËûËùÓÐ¶ÓÁÐ¡£\nÈË¿ÚÑ§ºÍÁÙ´²±äÁ¿µÄÓ°Ïì£º¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬·ÖÀàÆ÷ÆÀ·ÖÔÚAS»¼ÕßÖÐÈÔ±£³Ö½Ï¸ßË®Æ½£¬Ð£ÕýºóAUCÎª0.918£¨95%CI 0.884¨C0.951£©£¬±íÃ÷ÆäÐÔÄÜ²¢·Ç½öÓÉÉö¹¦ÄÜ»òÈË¿ÚÑ§ÌØÕ÷²îÒìÇý¶¯¡£\n·ÖÀàÆ÷ËæÊ±¼ä±ä»¯µÄÆÀ¹À£º¶ÔÑéÖ¤¶ÓÁÐÖÐ17ÀýAS»¼ÕßµÄ×ÝÏòËæ·ÃÑù±¾·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ¸öÌåÄÚËæÊ±¼ä±£³ÖÒ»ÖÂ£¬ÇÒÊ¼ÖÕ¸ßÓÚÕï¶ÏãÐÖµ¡£ÖµµÃ×¢ÒâµÄÊÇ£¬Ò»ÃûÐ¯´ø°ëºÏ×ÓCOL4A5±äÒì£¨ÒâÒå²»Ã÷È·£©µÄ»¼ÕßÔÚËùÓÐËæ·ÃÊ±¼äµã¾ù±»·ÖÀàÎªÑôÐÔ¡£ÏßÐÔ»ìºÏÐ§Ó¦Ä£ÐÍÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÓë¼²²¡½øÕ¹£¨P=0.79£©¼°Ñª¹Ü½ôÕÅËØ×ª»»Ã¸ÒÖÖÆ¼Á£¨ACEi£©ÖÎÁÆ£¨P=0.66£©¾ùÎÞÏÔÖø¹ØÁª¡£\nÌÖÂÛÓë½áÂÛ\n±¾ÑÐ¾¿Ê×´Î¿ª·¢²¢ÑéÖ¤ÁËÓÃÓÚ¶ù¿ÆASÕï¶ÏµÄ¼²²¡ÌØÒìÐÔÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã·ÖÀàÆ÷ÔÚÑéÖ¤¶ÓÁÐÖÐÕ¹ÏÖ³ö×¿Ô½µÄÕï¶ÏÐÔÄÜ£¬·´Ó³ÁËÔçÆÚÂýÐÔÉöÔà²¡£¨CKD£©½×¶Î¶ù¿ÆASÏà¶ÔÓÚÆäËûÒìÖÊÐÔ¶ÓÁÐµÄÇ¿·Ö×Ó¶ÀÌØÐÔ¡£·ÖÀàÆ÷ÆÀ·ÖÔÚ×ÝÏòËæ·ÃÖÐ±£³ÖÎÈ¶¨£¬ÇÒÓë½øÕ¹×´Ì¬ÎÞÏÔÖø¹ØÁª£¬ÌáÊ¾¸ÃëÄ×éÑ§±êÖ¾Îï·´Ó³µÄÊÇÇ±ÔÚ¼²²¡ÉúÎïÑ§¶ø·Ç¶ÌÔÝµÄÁÙ´²²¨¶¯¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£ÕýºóÈÔ±£³ÖÇ¿¼ø±ðÐÔÄÜ£¬½øÒ»²½Ö¤ÊµÆäÎÈ½¡ÐÔ¡£\n´ÓÉúÎïÑ§½Ç¶È£¬·ÖÀàÆ÷ÖÐ°üº¬Ô´×Ô¶àÖÖµ°°×ÖÊµÄëÄ¶Î£¬°üÀ¨»ùµ×Ä¤Ïà¹ØIVÐÍ½ºÔÁ´ÒÔ¼°ÏËÎ¬×´ºÍÏ¸°ûÍâ»ùÖÊÏà¹Ø½ºÔ£¬ÕâÓëASµÄ²¡ÀíÉúÀí¸ß¶ÈÒ»ÖÂ¡£´ËÍâ£¬»¹°üº¬Ô´×ÔÄòµ÷½ÚËØ¡¢²¹ÌåC3ºÍ»ùµ×Ä¤ÌØÒìÐÔÁòËáÒÒõ£¸ÎËØµ°°×¾ÛÌÇµÄëÄ¶Î£¬ÌáÊ¾ÉöÐ¡¹ÜËðÉË¡¢Ñ×Ö¢¼¤»îºÍ»ùµ×Ä¤ÖØËÜÒ²¿ÉÄÜ²ÎÓë¶ù¿ÆASµÄ·Ö×ÓÌØÕ÷¡£±¾ÑÐ¾¿ÖÐ¶ù¿ÆAS±êÖ¾ÎïÓë¼ÈÍù±¨µÀµÄ³ÉÈËASÄòÒºëÄ×éÑ§±êÖ¾ÎïÖØµþ¼«ÉÙ£¬¿ÉÄÜÔÒò°üÀ¨ÄêÁäÏà¹ØµÄÄòÒºëÄ×é²îÒì¡¢ÒÅ´«·Ö²¼²îÒì£¨¶ù¿ÆÒÔCOL4A5±äÒìÎªÖ÷£¬³ÉÈËÒÔCOL4A3/COL4A4±äÒìÎªÖ÷£©ÒÔ¼°¼²²¡½×¶Î²îÒì£¨¶ùÍ¯¸ü·´Ó³Ô·¢ÐÔIVÐÍ½ºÔ¸Ä±ä£¬³ÉÈËÔò¸ü¶àÌåÏÖÏËÎ¬»¯ºÍ¹ã·ºÏ¸°ûÍâ»ùÖÊÖØËÜ£©¡£\nÑÐ¾¿½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖ×¼È·µÄÄòÒºëÄ×éÑ§·ÖÀàÆ÷£¬¿ÉÓÃÓÚ¶ù¿ÆASµÄÎÞ´´Õï¶Ï¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬ÓÈÆäÔÚÁÙ´²ÒÉËÆµ«·Ö×Ó¼ì²â½á¹û²»È·¶¨µÄ²¡ÀýÖÐ£¬ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£","full_text":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children\n        \n        \t\n            \t±à¼ÍÆ¼ö£º\n                \n                ¡¡¡¡ÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n                \n\t\t\t\t\n             \n            \n\t\t\t\n         \n        \n        ¡¡¡¡\nÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n·½·¨£º²ÉÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉµÄÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑéÖÐ57ÀýAS»¼¶ù£¨80.7%ÎªXÁ¬ËøÒÅ´«£¬Æ½¾ùÄêÁä10¡À4Ëê£¬Å®ÐÔÕ¼4%£¬Æ½¾ù¹ÀËãÉöÐ¡ÇòÂË¹ýÂÊ[eGFR]Îª128¡À31 mL/min/1.73 m2£©µÄ282·ÝÑù±¾£¬ÒÔ¼°À´×Ô¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxon¼ìÑé²¢¾Benjamini-HochbergÐ£Õý¼ø¶¨²îÒìëÄ£¬ÓÃÓÚ¹¹½¨Ö§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ºÍÔÚÑéÖ¤¶ÓÁÐÖÐµÄÓ¦ÓÃ½øÐÐÆÀ¹À¡£\n½á¹û£º¹²¼ø¶¨³ö151ÖÖ²îÒìëÄ¡£ÆäÖÐ87ÖÖëÄ¾ßÓÐÐòÁÐÐÅÏ¢²¢ÓÃÓÚ·ÖÀàÆ÷Éú³É£»60.9%Îª½ºÔµ°°×ÑÜÉúëÄ¡£ÔÚÑéÖ¤ÖÐ£¬¸Ã·ÖÀàÆ÷µÄÊÜÊÔÕß¹¤×÷ÌØÕ÷ÇúÏßÏÂÃæ»ý£¨AUC£©´ïµ½0.999£¨95%ÖÃÐÅÇø¼ä[CI] 0.997¨C1.000£©£¬ÁéÃô¶ÈÎª100%£¬ÌØÒì¶ÈÎª97.4%£¬×¼È·ÂÊÎª98.2%¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬ÆäÐÔÄÜÈÔÈ»½Ï¸ß£¨Ð£ÕýºóAUCÎª0.918£¬95% CI 0.884¨C0.951£©¡£×ÝÏò·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ³¤´ï3ÄêµÄËæ·ÃÆÚÄÚ±£³ÖÎÈ¶¨¡£\n½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖÓÃÓÚ¶ù¿ÆASÎÞ´´Õï¶ÏµÄ×¼È·ÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬²¢ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£\nÑÐ¾¿±³¾°ÓëÄ¿µÄ\nÒÅ´«ÐÔÉö²¡ÊÇ¶ùÍ¯ÖÕÄ©ÆÚÉö²¡µÄÖ÷ÒªÔÒòÖ®Ò»£¬ÆäÖÐAlport×ÛºÏÕ÷£¨AS£©ÊÇÓÉCOL4A3¡¢COL4A4»òCOL4A5»ùÒòÖÂ²¡ÐÔ±äÒìÒýÆðµÄÒÅ´«ÐÔÉöÔà¼²²¡£¬µ¼ÖÂIVÐÍ½ºÔ½á¹¹Òì³£ºÍ½øÐÐÐÔÉöÐ¡Çò»ùµ×Ä¤£¨GBM£©ËðÉË¡£ASÁÙ´²±íÏÖ¶àÑù£¬´Ó¹ÂÁ¢ÐÔÑªÄòµ½½øÐÐÐÔÂýÐÔÉöÔà²¡¡¢ÌýÁ¦É¥Ê§ºÍÑÛ²¿Òì³£²»µÈ¡£¶ùÍ¯ÆÚÔçÆÚÕï¶ÏÖÁ¹ØÖØÒª£¬ÒòÎªÊ¶±ðAS¿ÉÖ¸µ¼Ëæ·Ã²ßÂÔ¡¢¿ªÕ¹¼Ò×åÉ¸²é²¢¾¡ÔçÆô¶¯°üÀ¨ÉöËØ-Ñª¹Ü½ôÕÅËØÏµÍ³×è¶ÏÔÚÄÚµÄÉöÔà±£»¤ÖÎÁÆ£¬´Ó¶øÑÓ»º¼²²¡½øÕ¹¡£È»¶ø£¬¶ùÍ¯Õï¶ÏÃæÁÙÖî¶àÌôÕ½£ºÔçÆÚ±íÏÖÈç³ÖÐøÐÔ¾µÏÂÑªÄòÎª·ÇÌØÒìÐÔÖ¢×´£¬³£ÓëÆäËû¶ù¿ÆÉöÔà¼²²¡ÖØµþ£»¾¡¹Ü»ùÒò¼ì²âÒÑ³ÉÎªÕï¶ÏºËÐÄ£¬µ«ÏÖÓÐ²âÐò²ßÂÔÎÞ·¨¼ì³öËùÓÐÖÂ²¡±äÒì£¬Ô¼20%µÄÁÙ´²ÒÉËÆ»¼ÕßÎ´ÄÜÍ¨¹ý»ùÒò¼ì²âÈ·¶¨ÖÂ²¡±äÒì£¬ÔÒò°üÀ¨È«ÍâÏÔ×Ó×é²âÐòµÄ¼¼Êõ¾ÖÏÞ¡¢·Ç¾µä¼ô½Ó±äÒìµÄ¼ì²âÀ§ÄÑ¡¢Ç¶ºÏÌåÏÖÏóÒÔ¼°ÆäËûÉöÔà¼²²¡µ¼ÖÂµÄ±íÐÍÄ£ÄâµÈ¡£Éö»î¼ìËä¿ÉÌá¹©¶îÍâÕï¶ÏÐÅÏ¢£¬µ«ÆäÎªÇÖÈëÐÔ¼ì²é£¬ÇÒ¹â¾µÏÂ×éÖ¯Ñ§·¢ÏÖ¿ÉÄÜ·ÇÌØÒìÐÔ¡£ÕâÐ©¾ÖÏÞÐÔ´ÙÊ¹ÑÐ¾¿Õß¶Ô»ùÓÚÄòÒºµÄ·ÇÇÖÈëÐÔ·½·¨²úÉúÐËÈ¤£¬ÒÔÆÚÖ§³Ö¸üÔç¡¢¸ü±ã½ÝµÄAS¼ì²â¡£\nÑÐ¾¿·½·¨Óë½áÂÛ\nÑÐ¾¿ÈËÔ±ÀûÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑé£¨NCT01485978£©ÖÐ57ÀýAS»¼¶ùµÄ282·ÝÄòÒºÑù±¾£¬ÒÔ¼°À´×Ô¶à¸ö¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾×÷Îª±È½Ï¶ÓÁÐ£¬°üÀ¨ÏÈÌìÐÔÉöÔàºÍÄòÂ·»ûÐÎ£¨CAKUT£©¡¢¹£×èÐÔÄòÂ·²¡£¨OU£©¡¢³£È¾É«ÌåÒþÐÔÒÅ´«¶àÄÒÉö²¡£¨ARPKD£©¡¢ÉöÏûºÄÖ¢¡¢1ÐÍÌÇÄò²¡¡¢ÉöÄÒÖ×ºÍÌÇÄò²¡×ÛºÏÕ÷£¨RCAD£©»¼¶ù¼°½¡¿µ¶ùÍ¯¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxonÖÈºÍ¼ìÑé²¢¾Benjamini-Hochberg´íÎó·¢ÏÖÂÊ£¨FDR£©Ð£Õý½øÐÐÅä¶Ô±È½Ï£¬É¸Ñ¡³öÔÚËùÓÐ±È½ÏÖÐ·½ÏòÒ»ÖÂÇÒFDR<0.05µÄ²îÒìëÄ£¬×îÖÕÀûÓÃ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢µÄëÄ¶Î¹¹½¨ÁË»ùÓÚ¾¶Ïò»ùº¯Êý£¨RBF£©ºËµÄÖ§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£·ÖÀàÆ÷ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ÆÀ¹À£¬²¢ÔÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐÖÐ½øÐÐÑéÖ¤¡£\nÑÐ¾¿½á¹û\nÑÐ¾¿ÈËÈºÌØÕ÷£ºAS»¼¶ùÕûÌåÉö¹¦ÄÜ±£´æÁ¼ºÃ£¬Æ½¾ùeGFRÎª128¡À31 mL/min/1.73m2£¬ÓëÌÇÄò²¡ºÍRCAD¶ÓÁÐÏàµ±£¬¶øCAKUT¡¢OU¡¢ARPKDºÍÉöÏûºÄÖ¢¶ÓÁÐµÄeGFRÏÔÖø½ÏµÍ¡£AS¶ÓÁÐÖÐÄÐÐÔÕ¼¾ø¶ÔÓÅÊÆ£¨96%£©£¬·ûºÏ¸ß±ÈÀýXÁ¬Ëø¼²²¡µÄÌØÕ÷£¨57Àý»¼ÕßÖÐ46ÀýÎªXÁ¬Ëø£¬9ÀýÎª³£È¾É«ÌåÒþÐÔÒÅ´«AS£¬2ÀýÒÅ´«Ä£Ê½Î´¶¨Òå£©¡£\n·ÖÀàÆ÷µÄ¶¨Òå£ºÔÚ20,192ÖÖ¹Û²ìµ½µÄëÄÖÐ£¬±£ÁôÖÁÉÙÔÚ30%Ñù±¾ÖÐ¼ì³öµÄ7,451ÖÖëÄ½øÐÐ·ÖÎö¡£ÎÞ¼à¶½½µÎ¬ÏÔÊ¾ASÑù±¾ÓëÆäËû×é±ðÃ÷ÏÔ·ÖÀë¡£Í¨¹ýÅä¶Ô±È½Ï¼ø¶¨³ö151ÖÖ²îÒìëÄ£¬ÆäÖÐ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢£¨¶ÔÓ¦36ÖÖµ°°×ÖÊ£©£¬53ÖÖ£¨61%£©Îª½ºÔµ°°×ÑÜÉúëÄ£¬63ÖÖ£¨72%£©ÔÚASÖÐ·á¶ÈÔö¼Ó£¬24ÖÖ£¨28%£©·á¶È½µµÍ¡£ÔÚ½»²æÑéÖ¤µÄ·¢ÏÖ¶ÓÁÐÖÐ£¬·ÖÀàÆ÷±íÏÖ³öÓÅÒìÐÔÄÜ£¬AUC´ï0.997£¨95%CI 0.995¨C0.999£©£¬»ùÓÚYoudenÖ¸ÊýÈ·¶¨µÄ×î¼Ñ·ÖÀàãÐÖµÎª-0.196¡£\n·ÖÀàÆ÷µÄÑéÖ¤£º½«Ô¤¶¨ÒåãÐÖµÓ¦ÓÃÓÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐ£¬·ÖÀàÆ÷AUC´ï0.999£¨95%CI 0.997¨C1.000£©£¬ÁéÃô¶È100%£¬ÌØÒì¶È97.4%£¬×¼È·ÂÊ98.2%¡£AS»¼ÕßµÄ·ÖÀàÆ÷ÆÀ·ÖÏÔÖø¸ßÓÚÆäËûËùÓÐ¶ÓÁÐ¡£\nÈË¿ÚÑ§ºÍÁÙ´²±äÁ¿µÄÓ°Ïì£º¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬·ÖÀàÆ÷ÆÀ·ÖÔÚAS»¼ÕßÖÐÈÔ±£³Ö½Ï¸ßË®Æ½£¬Ð£ÕýºóAUCÎª0.918£¨95%CI 0.884¨C0.951£©£¬±íÃ÷ÆäÐÔÄÜ²¢·Ç½öÓÉÉö¹¦ÄÜ»òÈË¿ÚÑ§ÌØÕ÷²îÒìÇý¶¯¡£\n·ÖÀàÆ÷ËæÊ±¼ä±ä»¯µÄÆÀ¹À£º¶ÔÑéÖ¤¶ÓÁÐÖÐ17ÀýAS»¼ÕßµÄ×ÝÏòËæ·ÃÑù±¾·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ¸öÌåÄÚËæÊ±¼ä±£³ÖÒ»ÖÂ£¬ÇÒÊ¼ÖÕ¸ßÓÚÕï¶ÏãÐÖµ¡£ÖµµÃ×¢ÒâµÄÊÇ£¬Ò»ÃûÐ¯´ø°ëºÏ×ÓCOL4A5±äÒì£¨ÒâÒå²»Ã÷È·£©µÄ»¼ÕßÔÚËùÓÐËæ·ÃÊ±¼äµã¾ù±»·ÖÀàÎªÑôÐÔ¡£ÏßÐÔ»ìºÏÐ§Ó¦Ä£ÐÍÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÓë¼²²¡½øÕ¹£¨P=0.79£©¼°Ñª¹Ü½ôÕÅËØ×ª»»Ã¸ÒÖÖÆ¼Á£¨ACEi£©ÖÎÁÆ£¨P=0.66£©¾ùÎÞÏÔÖø¹ØÁª¡£\nÌÖÂÛÓë½áÂÛ\n±¾ÑÐ¾¿Ê×´Î¿ª·¢²¢ÑéÖ¤ÁËÓÃÓÚ¶ù¿ÆASÕï¶ÏµÄ¼²²¡ÌØÒìÐÔÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã·ÖÀàÆ÷ÔÚÑéÖ¤¶ÓÁÐÖÐÕ¹ÏÖ³ö×¿Ô½µÄÕï¶ÏÐÔÄÜ£¬·´Ó³ÁËÔçÆÚÂýÐÔÉöÔà²¡£¨CKD£©½×¶Î¶ù¿ÆASÏà¶ÔÓÚÆäËûÒìÖÊÐÔ¶ÓÁÐµÄÇ¿·Ö×Ó¶ÀÌØÐÔ¡£·ÖÀàÆ÷ÆÀ·ÖÔÚ×ÝÏòËæ·ÃÖÐ±£³ÖÎÈ¶¨£¬ÇÒÓë½øÕ¹×´Ì¬ÎÞÏÔÖø¹ØÁª£¬ÌáÊ¾¸ÃëÄ×éÑ§±êÖ¾Îï·´Ó³µÄÊÇÇ±ÔÚ¼²²¡ÉúÎïÑ§¶ø·Ç¶ÌÔÝµÄÁÙ´²²¨¶¯¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£ÕýºóÈÔ±£³ÖÇ¿¼ø±ðÐÔÄÜ£¬½øÒ»²½Ö¤ÊµÆäÎÈ½¡ÐÔ¡£\n´ÓÉúÎïÑ§½Ç¶È£¬·ÖÀàÆ÷ÖÐ°üº¬Ô´×Ô¶àÖÖµ°°×ÖÊµÄëÄ¶Î£¬°üÀ¨»ùµ×Ä¤Ïà¹ØIVÐÍ½ºÔÁ´ÒÔ¼°ÏËÎ¬×´ºÍÏ¸°ûÍâ»ùÖÊÏà¹Ø½ºÔ£¬ÕâÓëASµÄ²¡ÀíÉúÀí¸ß¶ÈÒ»ÖÂ¡£´ËÍâ£¬»¹°üº¬Ô´×ÔÄòµ÷½ÚËØ¡¢²¹ÌåC3ºÍ»ùµ×Ä¤ÌØÒìÐÔÁòËáÒÒõ£¸ÎËØµ°°×¾ÛÌÇµÄëÄ¶Î£¬ÌáÊ¾ÉöÐ¡¹ÜËðÉË¡¢Ñ×Ö¢¼¤»îºÍ»ùµ×Ä¤ÖØËÜÒ²¿ÉÄÜ²ÎÓë¶ù¿ÆASµÄ·Ö×ÓÌØÕ÷¡£±¾ÑÐ¾¿ÖÐ¶ù¿ÆAS±êÖ¾ÎïÓë¼ÈÍù±¨µÀµÄ³ÉÈËASÄòÒºëÄ×éÑ§±êÖ¾ÎïÖØµþ¼«ÉÙ£¬¿ÉÄÜÔÒò°üÀ¨ÄêÁäÏà¹ØµÄÄòÒºëÄ×é²îÒì¡¢ÒÅ´«·Ö²¼²îÒì£¨¶ù¿ÆÒÔCOL4A5±äÒìÎªÖ÷£¬³ÉÈËÒÔCOL4A3/COL4A4±äÒìÎªÖ÷£©ÒÔ¼°¼²²¡½×¶Î²îÒì£¨¶ùÍ¯¸ü·´Ó³Ô·¢ÐÔIVÐÍ½ºÔ¸Ä±ä£¬³ÉÈËÔò¸ü¶àÌåÏÖÏËÎ¬»¯ºÍ¹ã·ºÏ¸°ûÍâ»ùÖÊÖØËÜ£©¡£\nÑÐ¾¿½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖ×¼È·µÄÄòÒºëÄ×éÑ§·ÖÀàÆ÷£¬¿ÉÓÃÓÚ¶ù¿ÆASµÄÎÞ´´Õï¶Ï¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬ÓÈÆäÔÚÁÙ´²ÒÉËÆµ«·Ö×Ó¼ì²â½á¹û²»È·¶¨µÄ²¡ÀýÖÐ£¬ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£","reading_time_min":1,"extraction":{"state":"ok","confidence":0.9,"error":null,"explanation":"High confidence: full text extraction produced 5705 characters.","diagnostics_url":"/api/diagnose?url=https%3A//www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 5705 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":5705,"summary_length":5705,"usable_text_length":5705,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":5705,"summary_length":5705}}},"quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 5705 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":5705,"summary_length":5705,"usable_text_length":5705,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":5705,"summary_length":5705}},"actions":{"read":"/item/91531","export_markdown":"/api/items/91531/export?format=markdown","export_json":"/api/items/91531/export?format=json","diagnose":"/api/diagnose?url=https%3A//www.ebiotrade.com/newsf/2026-9/20260928000348291.htm"}},"digest":{"id":91531,"title":"儿童Alport综合征的无创诊断尿液肽组学标志物 - 生物通","url":"https://www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","source":"生物通","topic":"peptides","published_at":"2026-09-28T00:14:13+00:00","excerpt":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children ±à¼ÍÆ¼ö£º ¡¡¡¡ÕªÒª…","quality_bucket":"high","quality_reason":"High confidence: full text extraction produced 5705 characters.","reading_time_min":1,"cluster_id":null},"card":{"display_title":"儿童Alport综合征的无创诊断尿液肽组学标志物 - 生物通","subtitle":"生物通 · 2026-09-28","summary":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children ±à¼ÍÆ¼ö£º ¡¡¡¡ÕªÒª…","badges":["quality:high"],"links":{"read":"/item/91531","original":"https://www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","diagnose":"/api/diagnose?url=https%3A//www.ebiotrade.com/newsf/2026-9/20260928000348291.htm"},"quality_warning":null},"export":{"title":"儿童Alport综合征的无创诊断尿液肽组学标志物 - 生物通","url":"https://www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","summary":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children\n        \n        \t\n            \t±à¼ÍÆ¼ö£º\n                \n                ¡¡¡¡ÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n                \n\t\t\t\t\n             \n            \n\t\t\t\n         \n        \n        ¡¡¡¡\nÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n·½·¨£º²ÉÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉµÄÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑéÖÐ57ÀýAS»¼¶ù£¨80.7%ÎªXÁ¬ËøÒÅ´«£¬Æ½¾ùÄêÁä10¡À4Ëê£¬Å®ÐÔÕ¼4%£¬Æ½¾ù¹ÀËãÉöÐ¡ÇòÂË¹ýÂÊ[eGFR]Îª128¡À31 mL/min/1.73 m2£©µÄ282·ÝÑù±¾£¬ÒÔ¼°À´×Ô¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxon¼ìÑé²¢¾Benjamini-HochbergÐ£Õý¼ø¶¨²îÒìëÄ£¬ÓÃÓÚ¹¹½¨Ö§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ºÍÔÚÑéÖ¤¶ÓÁÐÖÐµÄÓ¦ÓÃ½øÐÐÆÀ¹À¡£\n½á¹û£º¹²¼ø¶¨³ö151ÖÖ²îÒìëÄ¡£ÆäÖÐ87ÖÖëÄ¾ßÓÐÐòÁÐÐÅÏ¢²¢ÓÃÓÚ·ÖÀàÆ÷Éú³É£»60.9%Îª½ºÔµ°°×ÑÜÉúëÄ¡£ÔÚÑéÖ¤ÖÐ£¬¸Ã·ÖÀàÆ÷µÄÊÜÊÔÕß¹¤×÷ÌØÕ÷ÇúÏßÏÂÃæ»ý£¨AUC£©´ïµ½0.999£¨95%ÖÃÐÅÇø¼ä[CI] 0.997¨C1.000£©£¬ÁéÃô¶ÈÎª100%£¬ÌØÒì¶ÈÎª97.4%£¬×¼È·ÂÊÎª98.2%¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬ÆäÐÔÄÜÈÔÈ»½Ï¸ß£¨Ð£ÕýºóAUCÎª0.918£¬95% CI 0.884¨C0.951£©¡£×ÝÏò·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ³¤´ï3ÄêµÄËæ·ÃÆÚÄÚ±£³ÖÎÈ¶¨¡£\n½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖÓÃÓÚ¶ù¿ÆASÎÞ´´Õï¶ÏµÄ×¼È·ÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬²¢ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£\nÑÐ¾¿±³¾°ÓëÄ¿µÄ\nÒÅ´«ÐÔÉö²¡ÊÇ¶ùÍ¯ÖÕÄ©ÆÚÉö²¡µÄÖ÷ÒªÔÒòÖ®Ò»£¬ÆäÖÐAlport×ÛºÏÕ÷£¨AS£©ÊÇÓÉCOL4A3¡¢COL4A4»òCOL4A5»ùÒòÖÂ²¡ÐÔ±äÒìÒýÆðµÄÒÅ´«ÐÔÉöÔà¼²²¡£¬µ¼ÖÂIVÐÍ½ºÔ½á¹¹Òì³£ºÍ½øÐÐÐÔÉöÐ¡Çò»ùµ×Ä¤£¨GBM£©ËðÉË¡£ASÁÙ´²±íÏÖ¶àÑù£¬´Ó¹ÂÁ¢ÐÔÑªÄòµ½½øÐÐÐÔÂýÐÔÉöÔà²¡¡¢ÌýÁ¦É¥Ê§ºÍÑÛ²¿Òì³£²»µÈ¡£¶ùÍ¯ÆÚÔçÆÚÕï¶ÏÖÁ¹ØÖØÒª£¬ÒòÎªÊ¶±ðAS¿ÉÖ¸µ¼Ëæ·Ã²ßÂÔ¡¢¿ªÕ¹¼Ò×åÉ¸²é²¢¾¡ÔçÆô¶¯°üÀ¨ÉöËØ-Ñª¹Ü½ôÕÅËØÏµÍ³×è¶ÏÔÚÄÚµÄÉöÔà±£»¤ÖÎÁÆ£¬´Ó¶øÑÓ»º¼²²¡½øÕ¹¡£È»¶ø£¬¶ùÍ¯Õï¶ÏÃæÁÙÖî¶àÌôÕ½£ºÔçÆÚ±íÏÖÈç³ÖÐøÐÔ¾µÏÂÑªÄòÎª·ÇÌØÒìÐÔÖ¢×´£¬³£ÓëÆäËû¶ù¿ÆÉöÔà¼²²¡ÖØµþ£»¾¡¹Ü»ùÒò¼ì²âÒÑ³ÉÎªÕï¶ÏºËÐÄ£¬µ«ÏÖÓÐ²âÐò²ßÂÔÎÞ·¨¼ì³öËùÓÐÖÂ²¡±äÒì£¬Ô¼20%µÄÁÙ´²ÒÉËÆ»¼ÕßÎ´ÄÜÍ¨¹ý»ùÒò¼ì²âÈ·¶¨ÖÂ²¡±äÒì£¬ÔÒò°üÀ¨È«ÍâÏÔ×Ó×é²âÐòµÄ¼¼Êõ¾ÖÏÞ¡¢·Ç¾µä¼ô½Ó±äÒìµÄ¼ì²âÀ§ÄÑ¡¢Ç¶ºÏÌåÏÖÏóÒÔ¼°ÆäËûÉöÔà¼²²¡µ¼ÖÂµÄ±íÐÍÄ£ÄâµÈ¡£Éö»î¼ìËä¿ÉÌá¹©¶îÍâÕï¶ÏÐÅÏ¢£¬µ«ÆäÎªÇÖÈëÐÔ¼ì²é£¬ÇÒ¹â¾µÏÂ×éÖ¯Ñ§·¢ÏÖ¿ÉÄÜ·ÇÌØÒìÐÔ¡£ÕâÐ©¾ÖÏÞÐÔ´ÙÊ¹ÑÐ¾¿Õß¶Ô»ùÓÚÄòÒºµÄ·ÇÇÖÈëÐÔ·½·¨²úÉúÐËÈ¤£¬ÒÔÆÚÖ§³Ö¸üÔç¡¢¸ü±ã½ÝµÄAS¼ì²â¡£\nÑÐ¾¿·½·¨Óë½áÂÛ\nÑÐ¾¿ÈËÔ±ÀûÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑé£¨NCT01485978£©ÖÐ57ÀýAS»¼¶ùµÄ282·ÝÄòÒºÑù±¾£¬ÒÔ¼°À´×Ô¶à¸ö¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾×÷Îª±È½Ï¶ÓÁÐ£¬°üÀ¨ÏÈÌìÐÔÉöÔàºÍÄòÂ·»ûÐÎ£¨CAKUT£©¡¢¹£×èÐÔÄòÂ·²¡£¨OU£©¡¢³£È¾É«ÌåÒþÐÔÒÅ´«¶àÄÒÉö²¡£¨ARPKD£©¡¢ÉöÏûºÄÖ¢¡¢1ÐÍÌÇÄò²¡¡¢ÉöÄÒÖ×ºÍÌÇÄò²¡×ÛºÏÕ÷£¨RCAD£©»¼¶ù¼°½¡¿µ¶ùÍ¯¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxonÖÈºÍ¼ìÑé²¢¾Benjamini-Hochberg´íÎó·¢ÏÖÂÊ£¨FDR£©Ð£Õý½øÐÐÅä¶Ô±È½Ï£¬É¸Ñ¡³öÔÚËùÓÐ±È½ÏÖÐ·½ÏòÒ»ÖÂÇÒFDR<0.05µÄ²îÒìëÄ£¬×îÖÕÀûÓÃ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢µÄëÄ¶Î¹¹½¨ÁË»ùÓÚ¾¶Ïò»ùº¯Êý£¨RBF£©ºËµÄÖ§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£·ÖÀàÆ÷ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ÆÀ¹À£¬²¢ÔÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐÖÐ½øÐÐÑéÖ¤¡£\nÑÐ¾¿½á¹û\nÑÐ¾¿ÈËÈºÌØÕ÷£ºAS»¼¶ùÕûÌåÉö¹¦ÄÜ±£´æÁ¼ºÃ£¬Æ½¾ùeGFRÎª128¡À31 mL/min/1.73m2£¬ÓëÌÇÄò²¡ºÍRCAD¶ÓÁÐÏàµ±£¬¶øCAKUT¡¢OU¡¢ARPKDºÍÉöÏûºÄÖ¢¶ÓÁÐµÄeGFRÏÔÖø½ÏµÍ¡£AS¶ÓÁÐÖÐÄÐÐÔÕ¼¾ø¶ÔÓÅÊÆ£¨96%£©£¬·ûºÏ¸ß±ÈÀýXÁ¬Ëø¼²²¡µÄÌØÕ÷£¨57Àý»¼ÕßÖÐ46ÀýÎªXÁ¬Ëø£¬9ÀýÎª³£È¾É«ÌåÒþÐÔÒÅ´«AS£¬2ÀýÒÅ´«Ä£Ê½Î´¶¨Òå£©¡£\n·ÖÀàÆ÷µÄ¶¨Òå£ºÔÚ20,192ÖÖ¹Û²ìµ½µÄëÄÖÐ£¬±£ÁôÖÁÉÙÔÚ30%Ñù±¾ÖÐ¼ì³öµÄ7,451ÖÖëÄ½øÐÐ·ÖÎö¡£ÎÞ¼à¶½½µÎ¬ÏÔÊ¾ASÑù±¾ÓëÆäËû×é±ðÃ÷ÏÔ·ÖÀë¡£Í¨¹ýÅä¶Ô±È½Ï¼ø¶¨³ö151ÖÖ²îÒìëÄ£¬ÆäÖÐ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢£¨¶ÔÓ¦36ÖÖµ°°×ÖÊ£©£¬53ÖÖ£¨61%£©Îª½ºÔµ°°×ÑÜÉúëÄ£¬63ÖÖ£¨72%£©ÔÚASÖÐ·á¶ÈÔö¼Ó£¬24ÖÖ£¨28%£©·á¶È½µµÍ¡£ÔÚ½»²æÑéÖ¤µÄ·¢ÏÖ¶ÓÁÐÖÐ£¬·ÖÀàÆ÷±íÏÖ³öÓÅÒìÐÔÄÜ£¬AUC´ï0.997£¨95%CI 0.995¨C0.999£©£¬»ùÓÚYoudenÖ¸ÊýÈ·¶¨µÄ×î¼Ñ·ÖÀàãÐÖµÎª-0.196¡£\n·ÖÀàÆ÷µÄÑéÖ¤£º½«Ô¤¶¨ÒåãÐÖµÓ¦ÓÃÓÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐ£¬·ÖÀàÆ÷AUC´ï0.999£¨95%CI 0.997¨C1.000£©£¬ÁéÃô¶È100%£¬ÌØÒì¶È97.4%£¬×¼È·ÂÊ98.2%¡£AS»¼ÕßµÄ·ÖÀàÆ÷ÆÀ·ÖÏÔÖø¸ßÓÚÆäËûËùÓÐ¶ÓÁÐ¡£\nÈË¿ÚÑ§ºÍÁÙ´²±äÁ¿µÄÓ°Ïì£º¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬·ÖÀàÆ÷ÆÀ·ÖÔÚAS»¼ÕßÖÐÈÔ±£³Ö½Ï¸ßË®Æ½£¬Ð£ÕýºóAUCÎª0.918£¨95%CI 0.884¨C0.951£©£¬±íÃ÷ÆäÐÔÄÜ²¢·Ç½öÓÉÉö¹¦ÄÜ»òÈË¿ÚÑ§ÌØÕ÷²îÒìÇý¶¯¡£\n·ÖÀàÆ÷ËæÊ±¼ä±ä»¯µÄÆÀ¹À£º¶ÔÑéÖ¤¶ÓÁÐÖÐ17ÀýAS»¼ÕßµÄ×ÝÏòËæ·ÃÑù±¾·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ¸öÌåÄÚËæÊ±¼ä±£³ÖÒ»ÖÂ£¬ÇÒÊ¼ÖÕ¸ßÓÚÕï¶ÏãÐÖµ¡£ÖµµÃ×¢ÒâµÄÊÇ£¬Ò»ÃûÐ¯´ø°ëºÏ×ÓCOL4A5±äÒì£¨ÒâÒå²»Ã÷È·£©µÄ»¼ÕßÔÚËùÓÐËæ·ÃÊ±¼äµã¾ù±»·ÖÀàÎªÑôÐÔ¡£ÏßÐÔ»ìºÏÐ§Ó¦Ä£ÐÍÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÓë¼²²¡½øÕ¹£¨P=0.79£©¼°Ñª¹Ü½ôÕÅËØ×ª»»Ã¸ÒÖÖÆ¼Á£¨ACEi£©ÖÎÁÆ£¨P=0.66£©¾ùÎÞÏÔÖø¹ØÁª¡£\nÌÖÂÛÓë½áÂÛ\n±¾ÑÐ¾¿Ê×´Î¿ª·¢²¢ÑéÖ¤ÁËÓÃÓÚ¶ù¿ÆASÕï¶ÏµÄ¼²²¡ÌØÒìÐÔÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã·ÖÀàÆ÷ÔÚÑéÖ¤¶ÓÁÐÖÐÕ¹ÏÖ³ö×¿Ô½µÄÕï¶ÏÐÔÄÜ£¬·´Ó³ÁËÔçÆÚÂýÐÔÉöÔà²¡£¨CKD£©½×¶Î¶ù¿ÆASÏà¶ÔÓÚÆäËûÒìÖÊÐÔ¶ÓÁÐµÄÇ¿·Ö×Ó¶ÀÌØÐÔ¡£·ÖÀàÆ÷ÆÀ·ÖÔÚ×ÝÏòËæ·ÃÖÐ±£³ÖÎÈ¶¨£¬ÇÒÓë½øÕ¹×´Ì¬ÎÞÏÔÖø¹ØÁª£¬ÌáÊ¾¸ÃëÄ×éÑ§±êÖ¾Îï·´Ó³µÄÊÇÇ±ÔÚ¼²²¡ÉúÎïÑ§¶ø·Ç¶ÌÔÝµÄÁÙ´²²¨¶¯¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£ÕýºóÈÔ±£³ÖÇ¿¼ø±ðÐÔÄÜ£¬½øÒ»²½Ö¤ÊµÆäÎÈ½¡ÐÔ¡£\n´ÓÉúÎïÑ§½Ç¶È£¬·ÖÀàÆ÷ÖÐ°üº¬Ô´×Ô¶àÖÖµ°°×ÖÊµÄëÄ¶Î£¬°üÀ¨»ùµ×Ä¤Ïà¹ØIVÐÍ½ºÔÁ´ÒÔ¼°ÏËÎ¬×´ºÍÏ¸°ûÍâ»ùÖÊÏà¹Ø½ºÔ£¬ÕâÓëASµÄ²¡ÀíÉúÀí¸ß¶ÈÒ»ÖÂ¡£´ËÍâ£¬»¹°üº¬Ô´×ÔÄòµ÷½ÚËØ¡¢²¹ÌåC3ºÍ»ùµ×Ä¤ÌØÒìÐÔÁòËáÒÒõ£¸ÎËØµ°°×¾ÛÌÇµÄëÄ¶Î£¬ÌáÊ¾ÉöÐ¡¹ÜËðÉË¡¢Ñ×Ö¢¼¤»îºÍ»ùµ×Ä¤ÖØËÜÒ²¿ÉÄÜ²ÎÓë¶ù¿ÆASµÄ·Ö×ÓÌØÕ÷¡£±¾ÑÐ¾¿ÖÐ¶ù¿ÆAS±êÖ¾ÎïÓë¼ÈÍù±¨µÀµÄ³ÉÈËASÄòÒºëÄ×éÑ§±êÖ¾ÎïÖØµþ¼«ÉÙ£¬¿ÉÄÜÔÒò°üÀ¨ÄêÁäÏà¹ØµÄÄòÒºëÄ×é²îÒì¡¢ÒÅ´«·Ö²¼²îÒì£¨¶ù¿ÆÒÔCOL4A5±äÒìÎªÖ÷£¬³ÉÈËÒÔCOL4A3/COL4A4±äÒìÎªÖ÷£©ÒÔ¼°¼²²¡½×¶Î²îÒì£¨¶ùÍ¯¸ü·´Ó³Ô·¢ÐÔIVÐÍ½ºÔ¸Ä±ä£¬³ÉÈËÔò¸ü¶àÌåÏÖÏËÎ¬»¯ºÍ¹ã·ºÏ¸°ûÍâ»ùÖÊÖØËÜ£©¡£\nÑÐ¾¿½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖ×¼È·µÄÄòÒºëÄ×éÑ§·ÖÀàÆ÷£¬¿ÉÓÃÓÚ¶ù¿ÆASµÄÎÞ´´Õï¶Ï¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬ÓÈÆäÔÚÁÙ´²ÒÉËÆµ«·Ö×Ó¼ì²â½á¹û²»È·¶¨µÄ²¡ÀýÖÐ£¬ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£","source":"生物通","date":"2026-09-28T00:14:13+00:00","content":"¡¶Kidney International Reports¡·£ºUrinary peptidomic signature for non-invasive diagnosis of Alport syndrome in children\n        \n        \t\n            \t±à¼ÍÆ¼ö£º\n                \n                ¡¡¡¡ÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n                \n\t\t\t\t\n             \n            \n\t\t\t\n         \n        \n        ¡¡¡¡\nÕªÒª\nÒýÑÔ£º¶ùÍ¯Alport×ÛºÏÕ÷£¨AS£©µÄÔçÆÚÕï¶ÏÈÔ¾ßÌôÕ½ÐÔ£¬ÒòÆäÔçÆÚ±íÏÖ·ÇÌØÒìÐÔ£¬ÇÒ²¿·ÖÁÙ´²ÒÉËÆ²¡ÀýÒòÎ´·¢ÏÖÖÂ²¡ÐÔ±äÒì»ò±äÒìÒâÒå²»Ã÷È·¶øÎÞ·¨»ñµÃÒÅ´«Ñ§È·Õï¡£ÄòÒºëÄ×éÑ§ÊÇÒ»ÖÖÓÐÇ°¾°µÄÎÞ´´ÉúÎï±êÖ¾Îï·½·¨¡£±¾ÑÐ¾¿Ö¼ÔÚ¿ª·¢²¢ÑéÖ¤Ò»ÖÖÓÃÓÚ¶ù¿ÆASµÄÄòÒºëÄ×éÑ§±êÖ¾Îï¡£\n·½·¨£º²ÉÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉµÄÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑéÖÐ57ÀýAS»¼¶ù£¨80.7%ÎªXÁ¬ËøÒÅ´«£¬Æ½¾ùÄêÁä10¡À4Ëê£¬Å®ÐÔÕ¼4%£¬Æ½¾ù¹ÀËãÉöÐ¡ÇòÂË¹ýÂÊ[eGFR]Îª128¡À31 mL/min/1.73 m2£©µÄ282·ÝÑù±¾£¬ÒÔ¼°À´×Ô¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxon¼ìÑé²¢¾Benjamini-HochbergÐ£Õý¼ø¶¨²îÒìëÄ£¬ÓÃÓÚ¹¹½¨Ö§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ºÍÔÚÑéÖ¤¶ÓÁÐÖÐµÄÓ¦ÓÃ½øÐÐÆÀ¹À¡£\n½á¹û£º¹²¼ø¶¨³ö151ÖÖ²îÒìëÄ¡£ÆäÖÐ87ÖÖëÄ¾ßÓÐÐòÁÐÐÅÏ¢²¢ÓÃÓÚ·ÖÀàÆ÷Éú³É£»60.9%Îª½ºÔµ°°×ÑÜÉúëÄ¡£ÔÚÑéÖ¤ÖÐ£¬¸Ã·ÖÀàÆ÷µÄÊÜÊÔÕß¹¤×÷ÌØÕ÷ÇúÏßÏÂÃæ»ý£¨AUC£©´ïµ½0.999£¨95%ÖÃÐÅÇø¼ä[CI] 0.997¨C1.000£©£¬ÁéÃô¶ÈÎª100%£¬ÌØÒì¶ÈÎª97.4%£¬×¼È·ÂÊÎª98.2%¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬ÆäÐÔÄÜÈÔÈ»½Ï¸ß£¨Ð£ÕýºóAUCÎª0.918£¬95% CI 0.884¨C0.951£©¡£×ÝÏò·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ³¤´ï3ÄêµÄËæ·ÃÆÚÄÚ±£³ÖÎÈ¶¨¡£\n½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖÓÃÓÚ¶ù¿ÆASÎÞ´´Õï¶ÏµÄ×¼È·ÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬²¢ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£\nÑÐ¾¿±³¾°ÓëÄ¿µÄ\nÒÅ´«ÐÔÉö²¡ÊÇ¶ùÍ¯ÖÕÄ©ÆÚÉö²¡µÄÖ÷ÒªÔÒòÖ®Ò»£¬ÆäÖÐAlport×ÛºÏÕ÷£¨AS£©ÊÇÓÉCOL4A3¡¢COL4A4»òCOL4A5»ùÒòÖÂ²¡ÐÔ±äÒìÒýÆðµÄÒÅ´«ÐÔÉöÔà¼²²¡£¬µ¼ÖÂIVÐÍ½ºÔ½á¹¹Òì³£ºÍ½øÐÐÐÔÉöÐ¡Çò»ùµ×Ä¤£¨GBM£©ËðÉË¡£ASÁÙ´²±íÏÖ¶àÑù£¬´Ó¹ÂÁ¢ÐÔÑªÄòµ½½øÐÐÐÔÂýÐÔÉöÔà²¡¡¢ÌýÁ¦É¥Ê§ºÍÑÛ²¿Òì³£²»µÈ¡£¶ùÍ¯ÆÚÔçÆÚÕï¶ÏÖÁ¹ØÖØÒª£¬ÒòÎªÊ¶±ðAS¿ÉÖ¸µ¼Ëæ·Ã²ßÂÔ¡¢¿ªÕ¹¼Ò×åÉ¸²é²¢¾¡ÔçÆô¶¯°üÀ¨ÉöËØ-Ñª¹Ü½ôÕÅËØÏµÍ³×è¶ÏÔÚÄÚµÄÉöÔà±£»¤ÖÎÁÆ£¬´Ó¶øÑÓ»º¼²²¡½øÕ¹¡£È»¶ø£¬¶ùÍ¯Õï¶ÏÃæÁÙÖî¶àÌôÕ½£ºÔçÆÚ±íÏÖÈç³ÖÐøÐÔ¾µÏÂÑªÄòÎª·ÇÌØÒìÐÔÖ¢×´£¬³£ÓëÆäËû¶ù¿ÆÉöÔà¼²²¡ÖØµþ£»¾¡¹Ü»ùÒò¼ì²âÒÑ³ÉÎªÕï¶ÏºËÐÄ£¬µ«ÏÖÓÐ²âÐò²ßÂÔÎÞ·¨¼ì³öËùÓÐÖÂ²¡±äÒì£¬Ô¼20%µÄÁÙ´²ÒÉËÆ»¼ÕßÎ´ÄÜÍ¨¹ý»ùÒò¼ì²âÈ·¶¨ÖÂ²¡±äÒì£¬ÔÒò°üÀ¨È«ÍâÏÔ×Ó×é²âÐòµÄ¼¼Êõ¾ÖÏÞ¡¢·Ç¾µä¼ô½Ó±äÒìµÄ¼ì²âÀ§ÄÑ¡¢Ç¶ºÏÌåÏÖÏóÒÔ¼°ÆäËûÉöÔà¼²²¡µ¼ÖÂµÄ±íÐÍÄ£ÄâµÈ¡£Éö»î¼ìËä¿ÉÌá¹©¶îÍâÕï¶ÏÐÅÏ¢£¬µ«ÆäÎªÇÖÈëÐÔ¼ì²é£¬ÇÒ¹â¾µÏÂ×éÖ¯Ñ§·¢ÏÖ¿ÉÄÜ·ÇÌØÒìÐÔ¡£ÕâÐ©¾ÖÏÞÐÔ´ÙÊ¹ÑÐ¾¿Õß¶Ô»ùÓÚÄòÒºµÄ·ÇÇÖÈëÐÔ·½·¨²úÉúÐËÈ¤£¬ÒÔÆÚÖ§³Ö¸üÔç¡¢¸ü±ã½ÝµÄAS¼ì²â¡£\nÑÐ¾¿·½·¨Óë½áÂÛ\nÑÐ¾¿ÈËÔ±ÀûÓÃÃ«Ï¸¹ÜµçÓ¾-ÖÊÆ×ÁªÓÃ¼¼Êõ£¨CE-MS£©Éú³ÉÄòÒºëÄÆ×£¬·ÖÎöÁËÀ´×ÔEARLY PRO-TECTÊÔÑé£¨NCT01485978£©ÖÐ57ÀýAS»¼¶ùµÄ282·ÝÄòÒºÑù±¾£¬ÒÔ¼°À´×Ô¶à¸ö¶ù¿ÆÉöÔà¼²²¡¶ÓÁÐºÍ½¡¿µ¶ÔÕÕ×éµÄ651·ÝÑù±¾×÷Îª±È½Ï¶ÓÁÐ£¬°üÀ¨ÏÈÌìÐÔÉöÔàºÍÄòÂ·»ûÐÎ£¨CAKUT£©¡¢¹£×èÐÔÄòÂ·²¡£¨OU£©¡¢³£È¾É«ÌåÒþÐÔÒÅ´«¶àÄÒÉö²¡£¨ARPKD£©¡¢ÉöÏûºÄÖ¢¡¢1ÐÍÌÇÄò²¡¡¢ÉöÄÒÖ×ºÍÌÇÄò²¡×ÛºÏÕ÷£¨RCAD£©»¼¶ù¼°½¡¿µ¶ùÍ¯¡£Êý¾Ý¼¯°´»¼Õß²ãÃæËæ»ú·ÖÎª·¢ÏÖ¶ÓÁÐ£¨70%£©ºÍÑéÖ¤¶ÓÁÐ£¨30%£©¡£Í¨¹ýWilcoxonÖÈºÍ¼ìÑé²¢¾Benjamini-Hochberg´íÎó·¢ÏÖÂÊ£¨FDR£©Ð£Õý½øÐÐÅä¶Ô±È½Ï£¬É¸Ñ¡³öÔÚËùÓÐ±È½ÏÖÐ·½ÏòÒ»ÖÂÇÒFDR<0.05µÄ²îÒìëÄ£¬×îÖÕÀûÓÃ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢µÄëÄ¶Î¹¹½¨ÁË»ùÓÚ¾¶Ïò»ùº¯Êý£¨RBF£©ºËµÄÖ§³ÖÏòÁ¿»ú£¨SVM£©·ÖÀàÆ÷¡£·ÖÀàÆ÷ÐÔÄÜÍ¨¹ý½»²æÑéÖ¤ÆÀ¹À£¬²¢ÔÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐÖÐ½øÐÐÑéÖ¤¡£\nÑÐ¾¿½á¹û\nÑÐ¾¿ÈËÈºÌØÕ÷£ºAS»¼¶ùÕûÌåÉö¹¦ÄÜ±£´æÁ¼ºÃ£¬Æ½¾ùeGFRÎª128¡À31 mL/min/1.73m2£¬ÓëÌÇÄò²¡ºÍRCAD¶ÓÁÐÏàµ±£¬¶øCAKUT¡¢OU¡¢ARPKDºÍÉöÏûºÄÖ¢¶ÓÁÐµÄeGFRÏÔÖø½ÏµÍ¡£AS¶ÓÁÐÖÐÄÐÐÔÕ¼¾ø¶ÔÓÅÊÆ£¨96%£©£¬·ûºÏ¸ß±ÈÀýXÁ¬Ëø¼²²¡µÄÌØÕ÷£¨57Àý»¼ÕßÖÐ46ÀýÎªXÁ¬Ëø£¬9ÀýÎª³£È¾É«ÌåÒþÐÔÒÅ´«AS£¬2ÀýÒÅ´«Ä£Ê½Î´¶¨Òå£©¡£\n·ÖÀàÆ÷µÄ¶¨Òå£ºÔÚ20,192ÖÖ¹Û²ìµ½µÄëÄÖÐ£¬±£ÁôÖÁÉÙÔÚ30%Ñù±¾ÖÐ¼ì³öµÄ7,451ÖÖëÄ½øÐÐ·ÖÎö¡£ÎÞ¼à¶½½µÎ¬ÏÔÊ¾ASÑù±¾ÓëÆäËû×é±ðÃ÷ÏÔ·ÖÀë¡£Í¨¹ýÅä¶Ô±È½Ï¼ø¶¨³ö151ÖÖ²îÒìëÄ£¬ÆäÖÐ87ÖÖ¾ßÓÐÐòÁÐÐÅÏ¢£¨¶ÔÓ¦36ÖÖµ°°×ÖÊ£©£¬53ÖÖ£¨61%£©Îª½ºÔµ°°×ÑÜÉúëÄ£¬63ÖÖ£¨72%£©ÔÚASÖÐ·á¶ÈÔö¼Ó£¬24ÖÖ£¨28%£©·á¶È½µµÍ¡£ÔÚ½»²æÑéÖ¤µÄ·¢ÏÖ¶ÓÁÐÖÐ£¬·ÖÀàÆ÷±íÏÖ³öÓÅÒìÐÔÄÜ£¬AUC´ï0.997£¨95%CI 0.995¨C0.999£©£¬»ùÓÚYoudenÖ¸ÊýÈ·¶¨µÄ×î¼Ñ·ÖÀàãÐÖµÎª-0.196¡£\n·ÖÀàÆ÷µÄÑéÖ¤£º½«Ô¤¶¨ÒåãÐÖµÓ¦ÓÃÓÚ¶ÀÁ¢ÑéÖ¤¶ÓÁÐ£¬·ÖÀàÆ÷AUC´ï0.999£¨95%CI 0.997¨C1.000£©£¬ÁéÃô¶È100%£¬ÌØÒì¶È97.4%£¬×¼È·ÂÊ98.2%¡£AS»¼ÕßµÄ·ÖÀàÆ÷ÆÀ·ÖÏÔÖø¸ßÓÚÆäËûËùÓÐ¶ÓÁÐ¡£\nÈË¿ÚÑ§ºÍÁÙ´²±äÁ¿µÄÓ°Ïì£º¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£Õýºó£¬·ÖÀàÆ÷ÆÀ·ÖÔÚAS»¼ÕßÖÐÈÔ±£³Ö½Ï¸ßË®Æ½£¬Ð£ÕýºóAUCÎª0.918£¨95%CI 0.884¨C0.951£©£¬±íÃ÷ÆäÐÔÄÜ²¢·Ç½öÓÉÉö¹¦ÄÜ»òÈË¿ÚÑ§ÌØÕ÷²îÒìÇý¶¯¡£\n·ÖÀàÆ÷ËæÊ±¼ä±ä»¯µÄÆÀ¹À£º¶ÔÑéÖ¤¶ÓÁÐÖÐ17ÀýAS»¼ÕßµÄ×ÝÏòËæ·ÃÑù±¾·ÖÎöÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÔÚ¸öÌåÄÚËæÊ±¼ä±£³ÖÒ»ÖÂ£¬ÇÒÊ¼ÖÕ¸ßÓÚÕï¶ÏãÐÖµ¡£ÖµµÃ×¢ÒâµÄÊÇ£¬Ò»ÃûÐ¯´ø°ëºÏ×ÓCOL4A5±äÒì£¨ÒâÒå²»Ã÷È·£©µÄ»¼ÕßÔÚËùÓÐËæ·ÃÊ±¼äµã¾ù±»·ÖÀàÎªÑôÐÔ¡£ÏßÐÔ»ìºÏÐ§Ó¦Ä£ÐÍÏÔÊ¾£¬·ÖÀàÆ÷ÆÀ·ÖÓë¼²²¡½øÕ¹£¨P=0.79£©¼°Ñª¹Ü½ôÕÅËØ×ª»»Ã¸ÒÖÖÆ¼Á£¨ACEi£©ÖÎÁÆ£¨P=0.66£©¾ùÎÞÏÔÖø¹ØÁª¡£\nÌÖÂÛÓë½áÂÛ\n±¾ÑÐ¾¿Ê×´Î¿ª·¢²¢ÑéÖ¤ÁËÓÃÓÚ¶ù¿ÆASÕï¶ÏµÄ¼²²¡ÌØÒìÐÔÄòÒºëÄ×éÑ§·ÖÀàÆ÷¡£¸Ã·ÖÀàÆ÷ÔÚÑéÖ¤¶ÓÁÐÖÐÕ¹ÏÖ³ö×¿Ô½µÄÕï¶ÏÐÔÄÜ£¬·´Ó³ÁËÔçÆÚÂýÐÔÉöÔà²¡£¨CKD£©½×¶Î¶ù¿ÆASÏà¶ÔÓÚÆäËûÒìÖÊÐÔ¶ÓÁÐµÄÇ¿·Ö×Ó¶ÀÌØÐÔ¡£·ÖÀàÆ÷ÆÀ·ÖÔÚ×ÝÏòËæ·ÃÖÐ±£³ÖÎÈ¶¨£¬ÇÒÓë½øÕ¹×´Ì¬ÎÞÏÔÖø¹ØÁª£¬ÌáÊ¾¸ÃëÄ×éÑ§±êÖ¾Îï·´Ó³µÄÊÇÇ±ÔÚ¼²²¡ÉúÎïÑ§¶ø·Ç¶ÌÔÝµÄÁÙ´²²¨¶¯¡£¾ÄêÁä¡¢ÐÔ±ðºÍeGFRÐ£ÕýºóÈÔ±£³ÖÇ¿¼ø±ðÐÔÄÜ£¬½øÒ»²½Ö¤ÊµÆäÎÈ½¡ÐÔ¡£\n´ÓÉúÎïÑ§½Ç¶È£¬·ÖÀàÆ÷ÖÐ°üº¬Ô´×Ô¶àÖÖµ°°×ÖÊµÄëÄ¶Î£¬°üÀ¨»ùµ×Ä¤Ïà¹ØIVÐÍ½ºÔÁ´ÒÔ¼°ÏËÎ¬×´ºÍÏ¸°ûÍâ»ùÖÊÏà¹Ø½ºÔ£¬ÕâÓëASµÄ²¡ÀíÉúÀí¸ß¶ÈÒ»ÖÂ¡£´ËÍâ£¬»¹°üº¬Ô´×ÔÄòµ÷½ÚËØ¡¢²¹ÌåC3ºÍ»ùµ×Ä¤ÌØÒìÐÔÁòËáÒÒõ£¸ÎËØµ°°×¾ÛÌÇµÄëÄ¶Î£¬ÌáÊ¾ÉöÐ¡¹ÜËðÉË¡¢Ñ×Ö¢¼¤»îºÍ»ùµ×Ä¤ÖØËÜÒ²¿ÉÄÜ²ÎÓë¶ù¿ÆASµÄ·Ö×ÓÌØÕ÷¡£±¾ÑÐ¾¿ÖÐ¶ù¿ÆAS±êÖ¾ÎïÓë¼ÈÍù±¨µÀµÄ³ÉÈËASÄòÒºëÄ×éÑ§±êÖ¾ÎïÖØµþ¼«ÉÙ£¬¿ÉÄÜÔÒò°üÀ¨ÄêÁäÏà¹ØµÄÄòÒºëÄ×é²îÒì¡¢ÒÅ´«·Ö²¼²îÒì£¨¶ù¿ÆÒÔCOL4A5±äÒìÎªÖ÷£¬³ÉÈËÒÔCOL4A3/COL4A4±äÒìÎªÖ÷£©ÒÔ¼°¼²²¡½×¶Î²îÒì£¨¶ùÍ¯¸ü·´Ó³Ô·¢ÐÔIVÐÍ½ºÔ¸Ä±ä£¬³ÉÈËÔò¸ü¶àÌåÏÖÏËÎ¬»¯ºÍ¹ã·ºÏ¸°ûÍâ»ùÖÊÖØËÜ£©¡£\nÑÐ¾¿½áÂÛ£ºÑÐ¾¿ÈËÔ±³É¹¦¿ª·¢²¢ÑéÖ¤ÁËÒ»ÖÖ×¼È·µÄÄòÒºëÄ×éÑ§·ÖÀàÆ÷£¬¿ÉÓÃÓÚ¶ù¿ÆASµÄÎÞ´´Õï¶Ï¡£¸Ã±êÖ¾Îï¿É×÷ÎªÒÅ´«¼ì²âµÄ²¹³äÊÖ¶Î£¬ÓÈÆäÔÚÁÙ´²ÒÉËÆµ«·Ö×Ó¼ì²â½á¹û²»È·¶¨µÄ²¡ÀýÖÐ£¬ÓÐÖúÓÚASµÄÔçÆÚÊ¶±ð¡£","confidence":0.9,"diagnostics_url":"/api/diagnose?url=https%3A//www.ebiotrade.com/newsf/2026-9/20260928000348291.htm","quality_bucket":"high","failure_kind":"none","retryable":false,"quality_reason":"High confidence: full text extraction produced 5705 characters.","quality_profile":{"profile_version":"extraction_quality.v2","bucket":"high","confidence":0.9,"failure_kind":"none","retryable":false,"retry_after_attempts":0,"reason":"High confidence: full text extraction produced 5705 characters.","operator_guidance":{"severity":"ok","recommended_action":"trust_full_text","next_step":"Use the extracted full text as the primary article source.","operator_label":"Ready","can_retry":false,"can_use_summary":false,"diagnostics_required":false},"content_depth":{"contract_version":"content_depth.v1","category":"full_text","label":"Full text","has_full_text":true,"has_summary":true,"content_length":5705,"summary_length":5705,"usable_text_length":5705,"source_field":"content"},"legacy_collapsed":false,"signals":{"extract_state":"ok","extract_error":null,"extract_retries":0,"content_length":5705,"summary_length":5705}},"tags":[],"format_contract_version":"news_item_formats.v1"}}}