{"id":45409,"topic":"ai","source":"Phys.org","title":"Combining AI protein design with laboratory evolution improves engineered enzymes - Phys.org","url":"https://phys.org/news/2026-07-combining-ai-protein-laboratory-evolution.html","url_hash":"7a9b4fc608cff56aff047bb34f4d74ef4d0c27ff","author":"","summary":"<a href=\"https://news.google.com/rss/articles/CBMiggFBVV95cUxQY0t2b2dIQXQ5Y2t3dUVabWZ6dzNTYy1xSTVFTTV2RTlIWEZCQkZ0b0htU0hRTTE5d3RYYXlVN0FnaE14TkdncEdDNXcyckwzOVdvZ2Z5SzNGU1lHWVZLYjdtbHBnX2ZCVzNKbVdaYWJxOXdqTmlDSkE1NDJDcHNWcjFB?oc=5\" target=\"_blank\">Combining AI protein design with laboratory evolution improves engineered enzymes</a>&nbsp;&nbsp;<font color=\"#6f6f6f\">Phys.org</font>","content":null,"image_url":null,"lang":"en","published_at":"2026-07-24T14:40:01+00:00","fetched_at":"2026-07-24T15:15:05+00:00","status":"read","starred":0,"extract_state":"failed","summary_auto":null,"cluster_id":null,"extract_retries":2,"extract_error":"http_403","contract_version":"news_item.v1","format_contract_version":"news_item_formats.v1","dedup_url":"https://phys.org/news/2026-07-combining-ai-protein-laboratory-evolution.html","quality_profile":{"profile_version":"extraction_quality.v2","bucket":"failed","confidence":0.0,"failure_kind":"http","retryable":false,"retry_after_attempts":0,"reason":"Low confidence: HTTP extraction failure (http_403).","operator_guidance":{"severity":"action_required","recommended_action":"manual_review","next_step":"Open diagnostics and review the original source manually before use.","operator_label":"Manual review","can_retry":false,"can_use_summary":false,"diagnostics_required":true},"content_depth":{"contract_version":"content_depth.v1","category":"summary_only","label":"Summary only","has_full_text":false,"has_summary":true,"content_length":0,"summary_length":383,"usable_text_length":383,"source_field":"summary"},"legacy_collapsed":false,"signals":{"extract_state":"failed","extract_error":"http_403","extract_retries":2,"content_length":0,"summary_length":383}},"news_item":{"id":45409,"canonical_url":"https://phys.org/news/2026-07-combining-ai-protein-laboratory-evolution.html","source_url":"https://phys.org/news/2026-07-combining-ai-protein-laboratory-evolution.html","title":"Combining AI protein design with laboratory evolution improves engineered enzymes - 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